不同剂量阿扎司琼预防术后静脉镇痛恶心呕吐的临床观察  

Azasetron for prevention of postoperative nausea and vomiting in patient controlled intravenous analgesia

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作  者:张玉龙[1] 李月光[1] 范志明[1] 曹锦芳[1] 

机构地区:[1]常州市苏州大学附属常州肿瘤医院麻醉科,213001

出  处:《实用疼痛学杂志》2007年第3期192-194,共3页Pain Clinic Journal

摘  要:目的比较不同剂量阿扎司琼预防术后静脉自控镇痛(PCIA)期间恶心呕吐的效果。方法选择ASAⅠ~Ⅱ级手术患者108例,随机分为A、B、C三组,每组36例。A组PCIA泵配方:吗啡10 mg+芬太尼0.8 mg+阿扎司琼5 mg;B组配方:吗啡10 mg+芬太尼0.8 mg+阿扎司琼10 mg; C组配方:吗啡10 mg+芬太尼0.8 mg。结果A、B组患者术后恶心呕吐发生率分别为11.1%(4/36例)、8.3%(3/36例),均显著低于C组33.3%(12/36例),且差异有统计学意义(P<0.05, P<0.01)。A组恶心呕吐发生率11.1%(4/36例)与B组8.3%(3/36例),比较差异无统计学意义(P>0.05)。结论阿扎司琼5 mg即可达到预防吗啡复合芬太尼术后PCIA恶心呕吐的效果。Objective To compare the clinical effects of azasetron in different dosages for preventing postoperative nausea and vomiting (PONV) in patient controlled intravenous analgesia (PCIA). Methods One hundred and eight patients ( ASA Ⅰ- Ⅱ) scheduled for operations were randomly divided into three groups with 36 each: In group A,the patients were administed morphine 10 mg,fentanyl 0. 8 mg and azasetron 5 mg diluted to 100 ml with normal saline. In group B,the patients were administed morphine 10 mg,fentanyl 0.8 mg and azasetron 10 mg were diluted to 100 ml with normal saline. In group C,the patients were administed morphine 10 mg and fentanyl 0. 8 mg were diluted to 100 ml were normal saline. Results The occurrence rate of PONV in group A ( 11.1% ,4/36 cases) and group B (8. 3%, 3/36 cases) was significantly lower than that in group C(33. 3% , 12/36 cases) ;while no significant difference between group A and group B. Conclusion Azasetron 5 mg can effectively prevent the occurrence rate of PONV during patient controlled intravenous analgesia.

关 键 词:阿扎司琼 镇痛 静脉 手术后恶心和呕吐 

分 类 号:R614[医药卫生—麻醉学]

 

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