维生素E微囊的制备及其稳定性研究  

Preparation of vitamin E microcapsules and its stability

作　　者：冯琳[1,2] 张红梅[1,2] 王景祥[1,2] 

机构地区：[1]济南军区总医院 [2]济南市第四医院内科

出　　处：《中国医院药学杂志》1997年第1期3-4,共2页Chinese Journal of Hospital Pharmacy

摘　　要：以明胶和ＣＭＣ－Ｎａ为囊材，采用复凝聚法制备维生素Ｅ微囊。通过正交实验选择最佳制备条件。用紫外分光光度法于波长２８５ｎｍ测定含量。对以不同浓度的ＣＭＣ－Ｎａ制备的微囊的包封率、外观形态和对维生素Ｅ稳定性的影响进行了考察。结果表明，０．５％ＣＭＣ－Ｎａ与０．５％明胶浓度配比为１∶２时，微囊质量最好，同时能有效提高维生素Ｅ的稳定性。To improve the stability of vitamin E(VitE),microcapsules containing VitE were prepared by coacervation method with gelatin and CMC Na as wall material.The best conditions were selected with orthogonal design.VitE in the microcapsules was determined by UV at 285nm.Stability of VitE,encapsulation efficiency and external form of the microcapsules being prepared with CMC Na of different concentration were observed.Results showed that when concentration of CMC Na was 0.5 %,propotion of solution of CMC Na and 5% gelatin was 1∶2,the quality of the microcapsules was the highest and VitE in the microcapsules was stable.

关 键 词：维生素E 微囊 稳定性 制备 

分 类 号：TQ466.5[化学工程—制药化工] R977.25[医药卫生—药品]