血清中环丙沙星的微量微生物测定法  

Determination of ciprofloxacin in human serum by microbiologic assay

作　　者：凌骝[1,2] 陆瑶华[1,2] 曹杏娣[1,2] 宗黎琼[1,2] 

机构地区：[1]上海市第六人民医院 [2]河南郑州铁路局医院

出　　处：《中国医院药学杂志》1997年第1期32-33,共2页Chinese Journal of Hospital Pharmacy

摘　　要：微量微生物法测定血清中环丙沙星浓度的各项方法学指标均符合要求，不需特殊的仪器和试剂，操作简便、取样量少。试验菌选用枯草或大肠杆菌，两菌的测定结果经统计学处理无显著差异（Ｐ＞０．０５）。适用于体内药物浓度监测。Serum concentration of ciprofloxacin(CPFX) was determined by microbiologic assay. The methodology was studied.The method was simple,small quantity of sample was needed special instruments and reagents were not required.Bacillus subtilis or escherichia coli was selected as experimental bacteria.Statistically,the results from the two bacteria showed no significant difference( P < 0.05 ).It is suggested that the method was suitable to the determination of serum concentration in human.

关 键 词：环丙沙星 微量微生物法 血药浓度 

分 类 号：R978.19[医药卫生—药品]