血清孕酮及β-hCG测定诊断异位妊娠的价值  

The value of serum progesterone and β-hCG levels in the diagnosis of ectopic pregnancy.

作　　者：杜成杰[1] 石一复[1] 罗勤[1] 何晓红[1] 

机构地区：[1]浙江医科大学附属妇产科医院

出　　处：《中国实用妇科与产科杂志》1997年第1期35-36,共2页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：测定了１０１例异位妊娠（ＥＰ）、４９例正常宫内孕（ＮＩＵＰ）、２４例先兆流产（ＴＡ）及３２例难免流产（ＩＡ）妇女血清孕酮（Ｐ）和β－ｈＣＧ水平及２６例ＥＰ妇女间隔４８～７２小时的血清β－ｈＣＧ水平。结果：血清Ｐ水平均值在ＥＰ与ＮＩＵＰ或ＴＡ组间有非常显著差异（Ｐ＜０．００１），在ＥＰ与ＩＡ组间及未破裂型ＥＰ（ＵＲＥＰ）与破裂型ＥＰ（ＲＥＰ）组间的差异无显著性（Ｐ＞０．０５）。以血清Ｐ４９．２ｎｍｏｌ／Ｌ为临界值筛选ＥＰ与ＮＩＵＰ、ＴＡ、ＩＡ，其敏感性为９３．１％，特异性分别为７５．５％、８３．３％、２１．２％。血清β－ｈＣＧ水平均值在ＵＲＥＰ与ＲＥＰ组间亦有非常显著差异（Ｐ＜０．００１）。２６例ＥＰ患者间隔４８～７２ｈ血清β－ｈＣＧ水平上升率均＜６０．０％。指出血清Ｐ测定对ＥＰ与ＮＩＵＰ及ＴＡ筛选的价值大，并认为血清β－ｈＣＧ接近８０００ＩＵ／Ｌ的ＥＰ患者，应视为有破裂高危的病例。Objective:To assess the value of serum progesterone(P) levels in the early diagnosis of ectopic pregnancy(EP) and serum β-hCG levels in predicting rupture risk of EP.Design:Serum was collected in 101 cases with EP,49 cases with normal intrauterine pregnancy(NIUP),24 cases with threatened aboreton(TA) and 32 cases with inevitable abortion(IA)before discontinuing pregnancy,and the quantitative assays of P and β-hCG were made by RIA.Results:Mean serum P levels were significantly different between EP group and NIUP or TA group (P<0.001),but the difference was not significant between EP group and IA group or unruptured EP(UREP)group and ruptured EP(REP)group(P>0.05).49.2nmol/L of serum P was chosen as predictive threshold for screening of EP,NIUP,TA and IA,with sensitivity of 93.1%,specificity of 75.5%,83.3% and 21.2% respectively.Mean serum β-hCG levels were significantly different between UREP group and REP group(P<0.001).Conclusion:The results suggested that the serum P assay was great valuable in screening EP and IA,and there was a high risk of rupture in patients with EP whose serum β-hCG levels were near 8000IU/L. \ \

关 键 词：异位妊娠 孕酮 Β-HCG 测定 

分 类 号：R714.220.4[医药卫生—妇产科学]