妊高征患者红细胞膜Na^+-K^+-ATP酶活性及钙结合量减低及其意义的探讨  

Study on Na + K + ATPase Activity and Calcium binding Capacity of Erythrocyte Membrane and their Significantes in Pregnancy Induced Hypertension

作　　者：李红[1] 卢振敏[1] 符云峰[1] 李军[2] 耿岩 

机构地区：[1]河北省医学科学院 [2]河北省人民医院

出　　处：《中国妇幼保健》1997年第1期31-32,共2页Maternal and Child Health Care of China

摘　　要：妊高征病人红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性０．３１±０．１１μｍｏｌｐｉ／ｍｇ蛋白·小时－１，膜内面Ｃａ结合量５０．００±１７．５０ｎｍｏｌ／ｍｇ蛋白，正常孕妇红细胞膜以上两项指标分别为０．４５±０．１３μｍｏｌｐｉ／ｍｇ蛋白·小时－１和６９．６±１９．１２ｎｍｏｌ／ｍｇ蛋白。将两组同一指标进行统计学分析，Ｐ均小于０．０１，具有显著性差异。提示妊高征时细胞膜钠泵功能和膜内面结合Ｃａ的能力减低，这些变化可能与妊高征高血压的发生和发展有一定关系。Sodium potassium ATPase activity of erythrocyte membrane was measured in 29 cases of women with pregnancy induced hypertension(PIH) and 24 cases of normal pregnancy women matched to the cases of PIH on age and pregnancy weeks. Na + K + ATPase activity being 0 31±0 11μmol pi/mg protein·h -1 in hypertensive complications of pregnancy, which are significantly lower than that in matched normal pregnant women being 0 45±0 13μmol pi/mg protein·h -1 (P<0 01). The calcium binding capacity of erythrocyte membrane in pregnancy being 50 0±17 5nmol/mg protein, which is significantly lower than that normal pregnant women being 69 6±19 12nmol/mg protein(P<0 01).This suggest that the decreased Na + K + ATPase activity of cell membrane in women with PIH may be linked with the pathogenesis of the hypertension during pregnancy.

关 键 词：妊娠高血压 综合征 红细胞膜 钠 钾 ATP酶 

分 类 号：R714.246[医药卫生—妇产科学]