他汀类药物对冠状动脉血运重建患者院内不良事件的影响  

Impact of statins on hospital clinic outcomes in patients undergoing coronary revascularization

作　　者：贺立群[1] 冯义柏[1] 马长生[2] 聂绍平[2] 吕树铮[2] 顾承雄[2] 吴学思[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院,湖北武汉430022 [2]首都医科大学附属北京安贞医院

出　　处：《山东医药》2007年第7期9-10,共2页Shandong Medical Journal

基　　金：国家重点基础研究发展规划资金资助项目(973计划)(2003CB17103)

摘　　要：目的评价患者院内使用他汀类药物治疗对冠状动脉血运重建患者院内临床结果的影响。方法3763例冠状动脉血运重建(PCI或CABG)患者根据院内是否使用他汀类降脂药物分为他汀治疗组与非他汀治疗组,对两组院内临床结果进行回顾性分析比较。结果非他汀治疗组患者的病死率(3.1%)、不良心脑血管事件发生率(4.3%)均明显高于他汀治疗组(1.4%、2.0%)。年龄、左室射血分数、住院使用阿司匹林以及住院使用他汀类药物是预测血运重建患者院内不良事件的危险因素。结论早期开始他汀类药物治疗有利于降低冠心病血运重建患者院内不良事件的发生率。[Objective] To evaluate the impact of statins on inhospital clinic outcomes in patients undergoing coronary revascularizatlon. [Methods] 3763 patients underwent coronary revascularization were randomly divided into two groups according to whether using statins or not. [Results] 2360 patients were treated with statins during hospital, and 1403 patients were treated without statins. 44 patients（3.1%） died in non-statlns group, 33 patients（1.4%） died in statins group, and the rates of main adverse cardiac cerebral events were high among statins nonusers （4.3% vs 2. 0% ,P〈0.01）. Logistic regression showed that age, left ventricular ejection fraction, using Aspirin and using statins during hospital were the risk predictor for hospital adverse clinic outcomes. [Conclusion] Early statins use reduces the hospital rate of adverse clinic events in patients undergoing coronary revascularization.

关 键 词：冠状动脉疾病 血运重建 他汀类药物 

分 类 号：R541.4[医药卫生—心血管疾病]