乙肝疫苗长期免疫地区乙肝病毒感染家庭聚集性变化趋势的观察  

Observation of the changing trend of family-clustering about hepatitis B virus infection in the area where hepatitis B vaccine had been used universally for a long time

作　　者：杨进业[1] 沈立萍[1] 莫兆军[1] 李荣成[1] 李艳萍[1] 韦增良[1] 董邕辉[1] 周开姣[1] 谭毅[1] 方孔雄[2] 韦少超[2] 余陶[3] 张文英[3] 张勇[3] 毕胜利[3] 

机构地区：[1]广西壮族自治区疾病预防控制中心,南宁530021 [2]广西隆安县疾病预防控制中心,532700 [3]中国疾病预防控制中心病毒病所,北京100052

出　　处：《应用预防医学》2007年第1期8-10,共3页Applied Preventive Medicine

基　　金：广西壮族自治区医疗卫生重点科研课题(合同号:重200511)

摘　　要：目的探讨乙肝疫苗长期免疫后的HBV感染家庭聚集性状况的变化。方法采用整群抽样和横断面调查的方法,用固相放射免疫法(SPRIA)检测乙肝两对半,结果与历史资料比较。结果(1)检测样本4 686份,平均HBsAg阳性率为7.5%;完整家庭82户,其中HBsAg阴性的家庭占76.8%;1户1例阳性的占20.7%,1户2例阳性的只占2.4%,与1981年比较显著下降。(2)母子672对,HBsAg母子匹配阳性占5.2%;1981年的调查母子匹配阳性率为57.2%;本次调查母子匹配HBV感染率为31.3%,1981年的调查母子匹配HBV感染率为96.4%;(3)祖辈母亲与父辈母亲的HBV感染率无差异,但祖辈子代感染率为80.8%,父辈子代为15.9%。结论在乙肝疫苗长期普种地区的家庭成员的HBV感染率显著下降,HBV家庭聚集状况得到缓解。Objective To survey the family-clustering status of hepatitis B virus infection in long - term HBV vaccine immunity aera.Methods Whole sampling and cross-sectional investigation were used to collect the blood samples of people. The HBV infective signal was tested by SPRIA and the results obtoired were used to compare with the past data. Results （1） The sample number was 4 686. The average positive rate of HBsAg was 7.5 %. The whole family number was 82. The percentage of the family in which all people were HBsAg negative was 76.8% ,of which one person was HBsAg positive was 20.7% ,of which two persons were HBsAg positive was only 2.4% .The rate was lower significantly than that in 1981. （2）We tested 672 pairs of mother and child. The percentage of which mother and child were both HBsAg positive was 5.2%, while that of 1981 was 57.2%. the percentage of which mother and child were both HBV infective was 31.3%, while that of 1981 was 96.4%. （3） There were no significant deference between mothers of forefather and father generations about HBV infective rate. But that rate of higher generation was 80.8%, more higher than father generation（ 15.9% ） .Conclusions The HBV infective rate of family members drop significantly in the area where HBV vaccine had been widely used for newborns for a long time. The family - clustering status of HBV has been relieved.

关 键 词：乙型肝炎病毒 家庭聚集性 流行 免疫预防 

分 类 号：R512.621[医药卫生—内科学]