雌激素受体α与精氨酸加压素在大鼠下丘脑室旁核的共表达  

Co-expression of Estrogen Receptor-α and Arginine Vasopressin in the Hypothalamic Paraventricular Nucleus of the Rat

作　　者：王智超[1] 王笑蕾[2] 武军元[1] 鲁亚平[3] 

机构地区：[1]新疆生产建设兵团塔里木畜牧科技重点实验室,新疆阿拉尔843300 [2]泰山医学院内科护理教研室,山东泰安271000 [3]安徽师范大学生命科学学院,安徽芜湖241000

出　　处：《塔里木大学学报》2007年第2期34-36,共3页Journal of Tarim University

基　　金：国家自然科学基金资助项目(编号:30470537)

摘　　要：本实验通过免疫组织化学单标及双标技术研究了大鼠下丘脑室旁核中精氨酸加压素与雌激素受体α的分布和共存。结果显示大鼠下丘脑室旁核中几乎所有的精氨酸加压素阳性细胞均呈现雌激素受体α阳性,提示ERα可能参与雌激素对下丘脑AVP神经元的神经内分泌和生理功能调节,共同参与调控动物的社会认知的巩固过程。Immunohistochemical method was used in the present study to show the distribution and co - existence of estrogen receptor - α and arginine vasopressin in the hypothalamic paraventricular nucleus of the rat. The results showed that almost all the positive cells of arginine vasopressin - immunoreactive （IR） neurons took on the positive of estrogen receptor - α. These results suggested that estrogen receptor - α probably participated in the mediation of neuroendocrine and Physiological function of estrogen to the AVP neurons, and in the consolidation process of regulating the social recognition of the animal.

关 键 词：雌激素受体Α 下丘脑室旁核 精氨酸加压素 共表达 

分 类 号：Q95[生物学—动物学] Q45