格列吡嗪平行催化氢波及其应用  

Parallel catalytic hydrogen wave of glipizide and its applications

作　　者：马淮凌[1] 曹广秀[1] 伊伟 

机构地区：[1]商丘师范学院化学系,商丘476000 [2]商丘市教育技术设备管理中心,商丘476000

出　　处：《药物分析杂志》2007年第6期925-928,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：河南省自然科学基金(No.0511020300);商丘市科技攻关项目(No.20055001)

摘　　要：目的:建立灵敏、快速地测定格列吡嗪的新方法。方法:采用单扫描极谱法研究了氧化剂过硫酸钾(K_2S_2O_8)存在时格列吡嗪产生的极谱催化波的性质。结果:在 Na_2HPO_4-KH_2PO_4(pH 7.4)缓冲溶液中,格列吡嗪产生1个催化氢波。加入1.0×10^(-2)mol·L^(-1)K_2S_2O_8溶液后,该催化氢波进一步被催化,产生1个较灵敏的平行催化氢波,峰电流约增加30倍,峰电位基本不变。新催化波的二阶导数峰峰电流 i_p^n 与格列吡嗪浓度在6.0×10^(-8)～4.0×10^(-6)mol·L^(-1)范围内呈线性关系(r=0.9980,n=8),检出限为3.0×10^(-8)nol·L^(-1)。结论:该方法可用于药物制剂中格列吡嗪的含量测定。Objective：To develop a polarographic method of parallel catalytic hydrogen wave for determination of glipizide. Methods ：The catalytic wave properties of glipizide in the presence of oxidant K2S2O8 was investigated by linear single sweep polarography. Results：The catalytic hydrogen wave of glipizide was detected at ca. - 1.36 V （vs. SCE） in 0. 06 mol · L ^- 1 Na2HPO4 - KH2PO4 （ pH 7.4 ） buffer solution. When 1.0 × 10 ^-2 mol · L^-1 K2S2O8 solution was present, the peak current increased by 30 times, and the peak potential was unchanged, produced a more sensitive parallel catalytic hydrogen wave. The peak current of the parallel catalytic hydrogen wave was rectilinear correlation to the glipizide concentration in the range of 6. 0 × 10^ -8 -4.0 × 10 ^-6 mol · L ^-1 （ r =0. 9980 ,n = 8）. The detection limit was 3.0 × 10^-8 mol · L^-1. Conclusion：This method can be applied to the determination of glipizide in pharmaceuticals without preliminary separation.

关 键 词：格列吡嗪 过硫酸钾(K2S2O8) 平行催化氢波 单扫描示波极谱法 

分 类 号：R917[医药卫生—药物分析学]