Isoverbascoside对HL-60细胞生长和超微结构的影响  

Effect of isoverbascoside on the multiplication and uitrastructure of HL-60 cells

作　　者：周红[1] 颜青[1] 林炳珍[1] 王宇昉 陈瑞川[1] 李忌[1] 郑荣梁[3] 贾忠健[3] 

机构地区：[1]厦门大学抗癌研究中心,厦门361005 [2]厦门大学生物系,厦门361005 [3]兰州大学生物系,兰州730000

出　　处：《癌症》1997年第1期29-31,共3页Chinese Journal of Cancer

基　　金：福建省自然科学基金;国家自然科学基金

摘　　要：HL-60细胞经5μmol/L 剂量的 Isoverbascoside 处理后,细胞生长显著受抑,生长抑制率达到34.5%;电镜观察结果表明;处理后的细胞,部分细胞核呈肾形,高尔基体发达,线粒体嵴数目增多,表明 Isoverbas-coside 能使 HL-60细胞的恶性程度降低。After treatment with 5μmol/L Isoverbascoside,the growth of HL-60 cells decreased re- markably,and the cellular growth inhibitory rate amounted to 34.5%.The results of electron micro- scope revealed that after treatment,part of the treated nuclei were kidneyshaped,the mitochondria and the Golgi complex tended to become typical in shape and structrue.All these suggested that Isoverbas- coside could reverse the maligant phenotypic characteristics of HL-60 cells.

关 键 词：HL-60细胞 诱导 分化 超微结构 中药 提取物 

分 类 号：R285[医药卫生—中药学]