碘缺乏对仔鼠大脑烯醇化酶发育的影响  

Effect of iodine deficiency on neuron specific enolase of developing cerebrum of rat

作　　者：闫玉芹[1,2,3,4] 刘家慧[1,2,3,4] 张桂华 李晓哲[1,2,3,4] 李健群[1,2,3,4] 原弘 山根敏子[1,2,3,4] 宫崎惠利子[1,2,3,4] 

机构地区：[1]天津医科大学内分泌研究所 [2]中国医学科学院中国协和医科大学放射医学研究所 [3]哈尔滨医科大学 [4]日本高知医科大学

出　　处：《中国地方病学杂志》1997年第2期65-67,共3页Chinese Jouranl of Endemiology

摘　　要：本实验以严重缺碘地区的粮食复制出接近人类的大鼠缺碘模型，用免疫组化方法研究了碘缺乏对仔鼠大脑ＮＳＥ阳性神经细胞发育的影响。结果显示：实验组Ｔ４水平在各日龄都较对照组低，仔鼠大脑从出生至生后３０日龄ＮＳＥ阳性神经细胞发育较对照组落后，ＮＳＥ免疫阳性产物较少，这种差别在海马区、齿状回、皮层更为明显。表明碘缺乏所致甲状腺功能低下是影响脑发育的直接因素，提示甲状腺素是通过影响ＮＳＥ而干扰能量代谢，造成大脑发育障碍。Although the iodine deficiency can cause endemic cretinism,mechanism of the disease is still unclear.In this experiment rat model of iodine deficiency disorders similar to humans was replicated with the food of severe endemic area. The influence of iodine deficiency on development of NSE positive neurons in postnatal rats from birth day to 60 days was studied by immunohistochemistry. The results showed that T 4 levels were lower in all experimental group than controls,the development of NSE positive neurons was retarded from birth day to 30 days postnatally and NSE postive reactivity was less,especially in the hippocampus,dentate gyrus and cerebral cortex of the experimental groups.This indicated that hypothyroidism induced by iodine deficiency was a direct factor of brain developmental retardation. The results suggested that thyroxine could interfere with brain development by brain energy metabolism concerned with NSE.

关 键 词：碘缺乏 烯醇化酶 NSE 甲状腺素 

分 类 号：R591.1[医药卫生—内科学]