碘硒联合缺乏对大鼠甲状腺重量血清激素及酶活性的影响  

Effect of combined iodine and selenium deficiency on thyroid weights,serum hormones and enzymatic activities of rats

作　　者：王丹娜[1,2,3] 陈秀洁[1,2,3] 闫玉芹[1,2,3] 李晓哲 石远双[1,2,3] 

机构地区：[1]中国地方病防治研究中心碘缺乏病所 [2]哈尔滨医科大学基础医学院 [3]松花江地区职工医院内科

出　　处：《中国地方病学杂志》1997年第1期17-19,共3页Chinese Jouranl of Endemiology

摘　　要：应用２×２析因实验设计将Ｗｉｓｔａｒ大鼠随机分为四组：Ｉ＋Ｓｅ＋、Ｉ＋Ｓｅ－、Ｉ－Ｓｅ＋、Ｉ－Ｓｅ－。观察了喂养１２周和３２周大鼠甲状腺重量，血清总Ｔ４、Ｔ３水平和血清碱性磷酸酶（ＡＫＰ）活性。结果表明，低碘组（Ｉ－Ｓｅ＋，Ｉ－Ｓｅ－）甲状腺重量明显增高，血清Ｔ４下降，Ｔ３变化不明显或代偿性升高。在低碘条件下低硒，１２周时甲状腺重量增加快于低碘加硒组，但是在３２周时，甲状腺重量虽然继续增加，其速度却明显慢于低碘加硒组。血清ＡＫＰ无论１２周还是３２周时，酶活性明显下降仅发生在低碘同时伴有低硒时（Ｉ－Ｓｅ－），当低碘加硒时（Ｉ－Ｓｅ＋），ＡＫＰ活性明显增加且与加碘组（Ｉ＋Ｓｅ＋，Ｉ＋Ｓｅ－）无显著性差别。上述结果提示，缺碘是造成甲状腺肿大的主要原因，缺硒１２周时具有加重甲状腺肿大的辅助作用。Chinese Research Centre for Endemic Disease Control Wistar rats were randomly divided into four groups, I +Se +,I +Se -,I -Se +, and I -Se -. The results showed that thyroid weight significantly increased and serum T 4 content decreased, but there was no effect on T 3 level,in two iodine-deficient groups (I Se ,I Se ).When there was combined iodine and selenium deficiency ,the thyroidweight increased more quickly than that of I Se group.However, the significant lower level of serum AKP activity occurred only in both iodine and selenium deficiency group.If selenium was supplemented,AKP activity rosed quickly. The findings indicated that iodone deficiency is main cause of goitre.

关 键 词：碘缺乏 硒缺乏 甲状腺激素 AKP T3 T4 

分 类 号：R591.1[医药卫生—内科学]