醛糖还原酶:心肌缺血损伤干预的新靶点  

Aldose reductase:a novel target for cardioprotective intervention after myocardial ischemia

作　　者：王俊杰[1] 康桢[1] 李茯梅[2] 杨天崙[3] 欧阳冬生[1] 

机构地区：[1]中南大学临床药理研究所,长沙410078 [2]湘南学院药理教研室,湖南郴州423000 [3]中南大学湘雅医院心内科,长沙410008

出　　处：《国际病理科学与临床杂志》2007年第3期211-213,共3页Journal of International Pathology and Clinical Medicine

基　　金：湖南省卫生厅科研计划项目(B2005116);长沙市科技计划重点项目(K061021-32)~~

摘　　要：醛糖还原酶是糖代谢多元醇通路的限速酶。最新研究表明:心肌缺血时醛糖还原酶活性增强,抑制醛糖还原酶可以通过保护糖酵解途径和抑制氧化应激,减轻心肌缺血损伤,改善缺血再灌注后心肌功能。醛糖还原酶抑制剂作为潜在的治疗心肌梗死的有效措施引起了研究者的关注。Aldose reductase is a key regulatory enzyme in the substrate flux via polyol pathway. Recent studies show that the activity of aldose reductase is increased in ischemic heart tissues. It may reduce ischemic injury and improve functional and metabolic recovery after ischemia-reperfusion in hearts to inhibit aldose reductase by preserving generation of ATP via glycolysis and attenuating oxidative stress. The considerable interest has been evoked in using of aldose reductase inhibitors as potential therapeutic adjuncts in treating evolving myocardial infarction.

关 键 词：醛糖还原酶 缺血损伤 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]