单核细胞趋化蛋白-1与糖尿病肾病  

Monocyte chemoattractant protein-1 and diabetic nephropathy

作　　者：郑茂[1] 叶山东[1] 

机构地区：[1]安徽医科大学附属省立医院内分泌科,合肥230001

出　　处：《国际病理科学与临床杂志》2007年第3期253-256,共4页Journal of International Pathology and Clinical Medicine

基　　金：安徽省教育厅自然科学研究资助项目(2006KJ318B)~~

摘　　要：单核细胞趋化蛋白-1(MCP-1)是一种特异性趋化因子,在糖尿病肾病(diabetic nephropathy,DN)的发生发展中起重要作用。代谢性因素如高糖(HG)、糖基化白蛋白(glycated albumin,Gly-Alb)、氧化应激,蛋白激酶C(protein kinase C,PKC)等和血流动力学因素如肾素-血管紧张素系统(RAS)等均可上调肾小球内皮细胞、系膜细胞(mesangial cell,MC)、小管上皮细胞(tubulus epithelial cells,TECs)中MCP-1基因和蛋白的表达,使单核/巨噬细胞在肾组织中聚集,通过多种机制引起肾脏损伤。Monocyte chemoattractant protein-1 （ MCP-1 ） is a specific chemokine to recruit monocytes from the circulation to the local renal, which plays an important role in the development and pro- gress of diabetic nephropathy. Not only metabolism factors such as hyperglycemia, glycated albumin （ Gly- Alb）, oxidative stress and protein kinase C（ PKC ）, but also hemodynamic factors like renin angiotensin system（RAS） can up-regulate the expressions of MCP-1 gene and protein in endothelial cells, mesangial cells（MC） and tubulus epithelial cells（TECs）. The activation and infiltration of macrophage induced by over-expression of MCP-1 can damage renal tissue through various mechanisms.

关 键 词：趋化因子 单核细胞趋化蛋白-1 糖尿病 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]