聚苯乙烯磺酸镧对腺嘌呤致大鼠慢性肾衰高磷血症的治疗作用  

Effect of polystyrene sulphur lanthanum on hyperphosphatemia in rats with chronic renal failure induced by adenine

作　　者：李杰[1] 王芃[1] 解砚英[1] 张强[1] 张秀芹[1] 林霞[1] 

机构地区：[1]山东省医学科学院药物研究所药理室

出　　处：《中国临床药理学与治疗学》2007年第5期530-534,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察聚苯乙烯磺酸镧对腺嘌呤致大鼠慢性肾衰高磷血症的影响。方法:以Yokozawz方法诱发大鼠慢性肾衰,将造模成功动物随机分为聚苯乙烯磺酸镧1.500、0.750、0.375g·kg-1·d-1剂量组、阳性对照组(碳酸钙咀嚼片组)、模型对照组、正常对照组,连续用药22d。实验过程中观察动物一般状况、进食量、大小便情况,自给药开始后7、14、21d称取动物体重,观察体重变化。分别于给药10、21d自大鼠颈静脉取血检测血清BUN、Cr、磷、钙、钾,同时检测红细胞计数(RBC)、血红蛋白(Hb)、血小板计数(PLT)及红细胞压积(HCT)。给药22d处死大鼠,摘取双侧肾脏,称重计算肾脏系数并进行病理组织学检查。结果:聚苯乙烯磺酸镧1.500g·kg-1·d-1组给药21d血清磷为(2.47±0.38)mmol/L,钙磷乘积为6.6±0.6,与模型对照组比较差异有统计学意义(P<0.05)。结论:聚苯乙烯磺酸镧可降低腺嘌呤所致大鼠肾衰模型血清磷水平。AIM： To observe the effect of polystyrene sulphur lanthanum on hyperphosphatemia in rat model with chronic renal failure induced by adenine. METHODS： Chronic renal failure of rats was induced by Yokozawz method through infusing adenine （ 0.3 g·kg^-1·d^-1 ） for 25 days, and then model rats were given polystyrene sulphur lanthanum （ 1. 500, 0. 750, 0. 375 g·kg^-1·d^-1 ） and positive drug for 22 days, and the adenine was given eontifiuously for another 10 days. During the experiment courses, the body weight, general status, appetite, urination and defecation were observed. And levels of BUN, Cr, P^3＋, Ca^2＋, K^＋ RBC, Hb, PLT,and HCT in blood were monitored after the drug was given for 10 and 21 days. Rats were killed for kidney pathology and a quotient calculation. RESULTS： The polystyrene sulphur lanthanum at a dose of 1.500 g·kg^-1·d^-1 could reduce the phosphor level significantly, and there was obviously different from that of control model group （ P 〈 0.05）. CONCLUTION： The polystyrene sulphur lanthanum can significantly reduce the phosphor level of rat with chronic renal failure induced by adenine.

关 键 词：聚苯乙烯磺酸镧 慢性肾功能衰竭 腺嘌呤 血磷 

分 类 号：R965.2[医药卫生—药理学] R730.53[医药卫生—药学]