系统性红斑狼疮患者血清B淋巴细胞刺激因子的水平研究  

Study on relationship of serum BLys levels in patients with systemic lupus erythematosus

作　　者：郭建晖[1] 鞠少卿[2] 倪红兵[2] 

机构地区：[1]江苏省海门市人民医院检验科,226100 [2]南通大学附属医院检验医学中心

出　　处：《检验医学与临床》2007年第7期609-610,共2页Laboratory Medicine and Clinic

摘　　要：目的研究系统性红斑狼疮(SLE)患者血清B淋巴细胞刺激因子(BLyS)蛋白水平,并探讨其与尿蛋白的关系。方法应用酶联免疫吸附试验(ELISA)法检测尿蛋白阳性组(17例)和尿蛋白阴性SLE患者组(20例)血清BLys水平,以健康志愿者(30例)作为对照。结果SLE患者血清BLys水平明显高于健康对照组(P<0.05),但尿蛋白阳性组血清BLys水平与尿蛋白阴性组差异无统计学意义(P>0.05)。结论SLE患者BLys水平升高,提示BLyS可能与SLE的发病有关。Objective To determine the serum B lymphocyte stimulator （Blys） levels in the patients with sys- temic lupus erythematosus（SLE）,and to investigate the relationship between serum BLyS and APRIL levels and proteinuria levels. Methods To measure the serum BLyS levels with enzyme linked immunosorbent assay（ELISA） in the patients with SLE, who were separated into the group with high values of proteinuria（7 cases） and the group with normal values of proteinuria（20 cases） , and 30 healthy volunteers. Results The serum BLyS level in SLE patients was significantly increased compared with the healthy controls（P〈0.05） ; there was no significant difference in serum BLyS levels between the groups with high values and normal values of proteinuria （P〉0. 05）. Conclusion The BLyS level is significantly elevated in SLE patients,which suggests that BLyS might be involved in the pathogenesis of SLE.

关 键 词：系统性红斑狼疮 B淋巴细胞刺激因子 尿蛋白 

分 类 号：R593.241[医药卫生—内科学]