5-氟尿嘧啶壳聚糖纳米微球的制备及表征  

Preparation and Characterization of Chitosan-loaded 5-Fu Microspheres

作　　者：刘秋香[1] 曾林涛[2] 梁艳[1] 覃彩芹[2] 

机构地区：[1]中国地质大学材料科学与化学工程学院,湖北武汉430074 [2]孝感学院化学系,湖北孝感432000

出　　处：《孝感学院学报》2007年第3期5-8,共4页JOURNAL OF XIAOGAN UNIVERSITY

基　　金：湖北省教育厅科研项目(Z200626001)

摘　　要：壳聚糖（CS）作载体，与三聚磷酸钠（TPP）和5-氟尿嘧啶（5-Fu）发生离子交联反应，制备具有缓释效能的5-氟尿嘧啶壳聚糖纳米微球，并以微球载药量、颗粒大小为指标设计优化了其制备方法，考察不同因数水平对微球的载药量的影响。用傅立叶红外光谱表征了其结构，用激光散射粒径仪测得微球的平均粒径为143～212nm。氟尿嘧啶壳聚糖微球最大载药量为48．3％，在pH7．1磷酸盐缓冲溶液中对氟尿嘧啶的缓释作用明显，释放周期较长，药物含量越大，药物从微球中释放出来的速率越快，可作为靶向药物控释体系。The antitumor drugs 5 -Fu- CS nanoparticles have been formed based on ionic gelation process of tripolyphosphate （TPP）, 5 - Fu and chitosan. In order to gain the best parameters for preparing nanoparticles, the influences of different factors on average drug loading efficiency and particle size were evaluated by single - factor designing method. The physicochemical properties of nanoparticles were investigated in detail by using FTIR, UV Vis spectra, and laser dynamic scattering analysis. The average drug loading efficiency was 47.1% and the mean particle size was 143 ～ 212 nm. The release characteristics of the nanoparticles were studied in phosphate buffer solution. The results indicate that chitosan may be useful as a carrier for sustained release of drugs.

关 键 词：氟尿嘧啶 壳聚糖 离子交联法 纳米微球 缓释 

分 类 号：O636.1[理学—高分子化学]