磷酸川芎嗪滴丸药物动力学研究  

Study on the pharmacokinetics of ligustrazine phosphate dripping pills in healthy volunteers

作　　者：耿新辉[1] 陈方剑[1] 于晶晶[1] 陈建国[1] 马涛[2] 李见春[2] 

机构地区：[1]蚌埠医学院药学系,2003年级安徽蚌埠233030 [2]蚌埠医学院药剂学教研室,安徽蚌埠233030

出　　处：《蚌埠医学院学报》2007年第4期403-405,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨磷酸川芎嗪滴丸药物动力学特征。方法:20名健康志愿者,单剂量口服磷酸川芎嗪滴丸200mg,采用高效液相色谱法(HPLC)测定血清中药物的浓度,DAS2.0程序计算药代动力学参数。结果:磷酸川芎嗪滴丸主要药代动力学参数:Ka为(0.151±0.144)min,Tmax为(40.5±15.5)min,Cmax为(1.7±0.3)μg/ml,t1/2β为(67.7±3.2)min,CL/F为(0.017±0.004)L.min-1.kg-1,AUC0-300min为(181.5±40.3)μg.min-1.ml-1,AUC(0-∞)为(209.6±46.6)μg.min-1.ml-1。结论:单剂量口服磷酸川芎嗪滴丸200mg最佳房室模型为二室模型。Objective：To studdy the pharmacokinetics of ligustrazine phosphate dripping pills. Methods：Twenty healthy volunteers were given a single oral dose of 200 mg ligustrazine phosphate dripping pills. The serum concentrations of ligustrazine were determined by high performance liquid chromatogram （ HPLC ）. The pharmacokinetic parameters were calculated with DAS2. 0 practical pharmacokinetics program. Results： The main pharmacokinetics parameters of ligustrazine phosphate dripping pills were as follows ： Ka was （0. 151 ±0. 144）min, Tmax was （40.5 ± 15.5）min,Cmax was （1.7 ±0.3） μg/ml,t1/2β was （67.7±3.2）min,CL/F was （0.017 ± 0. 004 ） L · min ^-1·kg^-1, AUC0-300 min was （ 181.5 ± 40.3 ）μg · min^-1·ml^-1 and AUC（0-∞） was （ 209.6 ± 46.6 ） μg · min^-1·ml^-1 ,respectively. Conclusions ：The preparation fits the two-compartment model best.

关 键 词：川芎嗪 高效液相色谱法 药物动力学 

分 类 号：R284.1[医药卫生—中药学]