小肽的分离方法及其肠道吸收研究进展  

The Research Progress of Small Peptide Separation Method and Its Intestinal Tract Absorption

作　　者：朱仁书[1] 晋佳路[1] 李炳宪[1] 

机构地区：[1]鹤壁职业技术学院,河南鹤壁458030

出　　处：《医学综述》2007年第12期891-893,共3页Medical Recapitulate

摘　　要：小肽(二肽和三肽)可以被肠道完整地吸收。小肽在肠道的吸收载体是肽载体Ⅰ型,与游离氨基酸相比,小肽具有转运速度快、耗能低、不易饱和等独特的吸收特点,使其成为目前研究的一个热点。开发小肽,研制新药,关键是分离小肽。目前分离小肽的方法主要有毛细管电泳、高效液相色谱法、柱层析法、毛细管电泳-电喷雾-质谱联用、纸电泳法等。Small peptide （SP）（ dipeptide or tripeptide） can be absorbed by the intestinal tract,of which the absorption cartier is pepT1.Compared with amino acid,the small peptide have specific absorption characteristics of rapid conveying speed, low energy consuming and uneasy saturation, which makes it become a hot spot in studying at present The key in developing small peptide and exploring new drug is to isolate small peptide.Up to now,the main methods in isolating SP are：Capillary Electrophoresis method（CE）, High Performance Liquid Chromatograph（HPLC） method, Column Chromatography （CC）, CE-ESI-MS combination, Filter Paper Electrophoresis Method and so on.

关 键 词：小肽 分离方法 吸收机制 载体 影响因素 

分 类 号：R977.4[医药卫生—药品]