蛋白激酶CK2与Wnt信号转导途径  

Wnt Signal Transduction Pathway and Protein Kinase CK2

作　　者：赵树勇[1] 刘新光[1] 

机构地区：[1]广东医学院生物化学与分子生物学教研室,广东湛江524023

出　　处：《医学综述》2007年第1期6-8,共3页Medical Recapitulate

基　　金：教育部科学技术研究重点项目(03096);广东省自然科学基金项目(05011579);广东省卫生厅科研基金项目(A2004454)

摘　　要：蛋白激酶CK2是一种真核中普遍存在的信使非依赖性丝/苏氨酸蛋白激酶,到目前为止,已发现其300多种底物,且数目还在增加,涉及到许多细胞生命过程,如从DNA复制、转录到细胞生长的信号转导、增殖、转化、细胞凋亡等。近来研究发现,CK2与Wnt信号转导途径存在着很大的联系,CK2可以与-βcatenin和dishevelled等Wnt信号蛋白相结合使它们磷酸化,正性调节Wnt信号转导途径。在肿瘤发生和早期胚胎发育过程中CK2增强Wnt信号转导,本文将从这两个方面加以综述。Protein kinase CK2 is a ubiquitous eukaryotic messenger-independent protein sorine/threonine kinase, more than 300 substrates of CK2 has been found to date, whoso number is still increasing. Those subsracts are involved in many cellular processes including cell growth, proliferation, transformation, apoptosis and so on. Recently study has found that CK2 has close relationship with Wnt Signal Transduction Pathway, which can hind with some wnt signal protein such as β-catenin and dishevelled and make them phosphorylation as well as positive relulate this signal pathway. CK2 can intensify wnt slngal transduction in tumourgenesis and early embryonic development. This review is just focused on this two aspects.

关 键 词：蛋白激酶CK2 Wnt信号转导 肿瘤发生 早期胚胎发育 

分 类 号：Q55[生物学—生物化学]