真性红细胞增多症诊断指标的评价  

Evaluation of Diagnosis Index of Polycythemia Vera

作　　者：潘湘涛[1] 陆晔[1] 夏学鸣[1] 

机构地区：[1]苏州大学附属太仓医院,江苏太仓215400

出　　处：《医学综述》2007年第8期597-599,共3页Medical Recapitulate

摘　　要：真性红细胞增多症(PV)是发生于造血干细胞水平的异常克隆性疾病,以血红蛋白和红细胞数量增高为主要特征。至今国内外尚无明确的特异性诊断指标,但最近的研究表明绝大多数PV患者中有内源性红系集落形成而血清促红细胞生成素降低,同时高表达促红细胞生成素受体基因而低表达血小板生成素受体基因;在染色体异常中9p杂合性缺失较有意义,但最特异的是JAK2V617F基因突变,而其他各种指标只是有一定鉴别意义的辅助指标。Polycythemia vera is a abnormal clone disease of hemopoietic stem cell,of which the characteristics is the increase of Hb and RBC.There is still no specific diagnosis index.But,recent study showed the patients with PV had endogenous erythroid colonies（EEC） and decreased serum Epo,and high expressed PRV-1 gene as well as lower expressed c-Mpl gene.The 9p heterozygosity deletion has big significance in chromosomal abnormality.but most specific marker was JAK2-V617F mutaion.Besides that,the other indexes can be considered as aided index with somewhat identification.

关 键 词：真性红细胞增多症 诊断 JAK2V617F基因突变 内源性红系集落形成 促红细胞生成素 

分 类 号：R555[医药卫生—血液循环系统疾病]