RNAi技术在抑制血管平滑肌细胞增殖中的研究进展  

Advances of RNA Interference for Inhibiting VSMC Hyperplasia

作　　者：刘苏健[1] 邓勇志[1] 

机构地区：[1]山西医科大学第二医院心胸外科,山西太原030001

出　　处：《心血管病学进展》2007年第4期620-622,共3页Advances in Cardiovascular Diseases

摘　　要：移植血管狭窄是影响冠脉旁路移植术后远期疗效的主要原因,其机理包括血管中膜平滑肌细胞表型转化、增殖、迁移至内膜并合成大量的细胞外基质。RNA干扰(RNAi)技术是一种沉默特异基因序列的基因治疗方法,现对其机理及在抑制血管平滑肌细胞增殖中的应用进展进行综述。Vein graft stenosis is a leading cause of graft failure in coronary artery bypass grafting surgery. Its mechanism includes media vascular smooth muscle cell （ VSMC ） phenotypical modulation, proliferation, migration to the intima and synthesis large number of extracellular matrix. RNA interference technology is a gene therapy which can silence special gene sequences. This paper reviews the principle of RNAi technology and its application advances in the field for inhibiting VSMC hyperplasia.

关 键 词：RNAI 移植血管狭窄 血管平滑肌细胞 增殖 

分 类 号：R654.2[医药卫生—外科学]