注射用加替沙星与注射用法莫替丁的配伍稳定性考察  

Compatibility of Gatifloxacin for Injection with Famotidine for Injection

作　　者：杨继章[1] 赵增仁[1] 刘瑞琴[1] 杨树民[1] 佟彬良[2] 

机构地区：[1]河北医科大学第一医院药剂科,石家庄市050031 [2]河北医科大学药学院,石家庄市050017

出　　处：《中国药房》2007年第20期1563-1565,共3页China Pharmacy

基　　金：河北省2004年医学科学研究重点课题(04177)

摘　　要：目的:考察注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在(20±1)℃条件下,分别观察及测定8h内配伍液的外观、pH值及紫外光谱的变化,并用紫外分光光度法测定加替沙星和法莫替丁的含量。结果:2药配伍后,8h内的pH值及含量均无明显变化;另在0.9%氯化钠注射液中8h内与5%葡萄糖注射液中6h内,配伍液的外观无明显变化。结论:注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。OBJECTIVE： To study the compatibility of gatifloxacin for injection with famotidine for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS：At room temperature （（20 ± 1）℃ ）for 8 hours, the changes of the mixture in appearance,pH and UV spectra were observed,and the contents of gatifloxacin and famotidine were determined by ultraviolet spectrophotometry.RESULTS：No significant change was found in pH values and contents within 8h after mixing of the two drugs,nor significant changes were found for the mixture in appearance within 8h in 0.9% sodium chloride injection or within 6h in 5% glucose injection.CONCLUSION： The mixture of gatifloxacin for injection and famotidine for injection were stable in 0.9% sodium chloride injection or 5% glucose injection.

关 键 词：注射用加替沙星 注射用法莫替丁 配伍 稳定性 紫外分光光度法 

分 类 号：R927.11[医药卫生—药学]