2-甲基-5,7-二氢噻吩并[3,4-d]嘧啶6,6-二氧化物的合成新方法  

A New Preparation Method of 2-methyl-5,7-dihydrothieno [3,4-d]Pyrimidine 6,6-dioxide

作　　者：张宝华[1] 史兰香[2] 

机构地区：[1]石家庄学院物理系,河北石家庄050035 [2]石家庄学院化工学院,河北石家庄050035

出　　处：《河北师范大学学报（自然科学版）》2007年第4期495-496,502,共3页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(20472008)

摘　　要：对4-氯-2-甲基-5,7-二氢噻吩并[3,4-d]嘧啶6,6-二氧化物为原料合成2-甲基-5,7-二氢噻吩并[3,4-d]嘧啶6,6-二氧化物的方法进行了改进.与文献报道的Pd-C/H2脱氯方法相比,用新的甲苯-锌粉-氢氧化钠溶液-TBAB体系常压脱氯,简便易行,避免了加氢脱氯的危险性,降低了成本,产物收率达92%.对反应条件进行了优化:甲苯为溶剂,TABA为相转移催化剂,n(4-氯嘧啶二氧化物)∶n(Zn)∶n(NaOH)=1∶10∶20,温度100℃,反应时间2 h.The improved synthesis method of 2- methyl- 5,7- dihydrothieno [ 3,4- d ] pyrimidine 6,6 - dioxide starting from 4 - chloro- 2- methyl- 5,7 - dihydrothieno [ 3,4 - d ] pyrimidine 6,6 - dioxide was reported. In this technology, the chlorine atom displacement reaction carried out in toluene-zinc-sodium hydroxide-TBAB system and the yield was up to 912 %, the operations were simple and easy, the danger from hydrogen reaction was avoided, the cost of product was decreased. The experimental results showed the toluene as a solvent, the TBAB as a phase transfer catalyst, n （4-chloropyrimidine dioxide） ： n （Zn） ： n （NaOH） = 1 ： 10：20, the reaction keeping at 100℃ for 2 h was the best reaction conditions.

关 键 词：2-甲基-5 7-二氢噻吩并[3 4-d]嘧啶6 6-二氧化物 除草剂 杀菌剂 合成 

分 类 号：O621.3[理学—有机化学]