微波辐射无溶剂KF-Al_2O_3催化苯甲醛与氰基乙酸乙酯的Knoevenagel缩合反应  

Knoevenagel Condensation of Benzaldehyde with Ethyl Cyanoacetate Catalyzed by KF-Al_2O_3 under Microwave Irradiation Without Solvent

作　　者：韩雪峰[1] 周秋香[2] 智永婷[1] 

机构地区：[1]廊坊师范学院化学与材料科学学院,河北廊坊065000 [2]廊坊师范学院材料化学研究所,河北廊坊065000

出　　处：《河北师范大学学报（自然科学版）》2007年第4期500-502,共3页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金(B2005000534);河北省博士基金(05547001-D)

摘　　要：采用KF-Al2O3为催化剂,在无溶剂微波辐射下苯甲醛与氰基乙酸乙酯发生Knoevenagel缩合反应,得到了较高的产率,并考察了反应条件对产率的影响.结果表明,当n(苯甲醛)∶n(氰基乙酸乙酯)=1∶1,催化剂用量为0.10 g,微波辐射功率为320 W,辐射2.0 min时,产率可达91.67%.Catalyzed by KF-Al2O3, Knoevenagel condensation of benzaldehyde with ethyl cyanoacetate under microwave irradiation without solvent has been found to proceed with high yield. The facts influencing the yield were studied and discussed briefly. The reaction conditions were： n （benzaldehyde）： n （ethyl cyanoacetate）= 1： 1, the quality of catalyst was 0.10 g, the power of microwave was 320 W, the irradiation time was 2.0 min, the yield was up to 91.67 %.

关 键 词：KNOEVENAGEL缩合 KF-AL2O3 无溶剂反应 微波辐射 

分 类 号：O625.67[理学—有机化学]