不同种系大鼠潜伏抑制模型的建立与评价  

The establishment and evaluation of latent inhibition model in SD and Wistar rats

作　　者：刘美[1] 王玮文[2] 邵枫[1] 

机构地区：[1]北京大学心理学系,北京100871 [2]中科院心理所心理健康重点实验室、中科院心理所脑-行为研究中心

出　　处：《中国行为医学科学》2007年第7期577-579,共3页Chinese Journal of Behavioral Medical Science

基　　金：国家自然科学基金资助项目（30670708,30500158）

摘　　要：目的建立潜伏抑制的实验动物模型。方法分别以SD和Wistar大鼠为实验对象，利用大鼠穿梭程序自动控制仪，观察了声音刺激的前呈现对随后的声音刺激一电击条件化联合学习的影响。结果与对照组动物相比，声音刺激的前呈现均能显著地降低SD和Wistar大鼠的条件化联合反应，即建立了潜伏抑制动物模型，进一步的分析表明，两个种系的动物在行为表现、条件化学习过程等方面存在一定的差异。在90次条件化训练中，无声音前呈现和有声音前呈现的2组Wistar大鼠的条件化反应次数[分别为（29．1±5．2）次，（17．8±10．2）次]显著地高于2组SD大鼠的条件化反应次数[分别为（16．5±10．7）次，（4．9±3．4）次]。结论与SD大鼠相比较而言，Wistar大鼠的潜伏抑制模型是一种更为理想的实验动物模型。Objective To establish an animal model of latent inhibition （LI）. Methods The model was established in both SD rats and Wistar rats. The effects of pre-exposed sound stimulus on subsequent sound-electric foot shock conditioned learning process were observed by computer-controlled automatic shuttle box. Results The LI models were successfully established. Compared to rats in control group, the conditioned learning of both SD rats and Wistar rats were retarded by the pre-exposure of sound stimulus. Furthermore, there were behavioral differences between SD rats and Wistar rats during the conditioning process. During the 90 trials, the correct reactions of Wistar rats（29.1±5.2,17.8±10.2） were significantly more than SD rats（ 16.5 ± 10.7,4.9 ± 3.4） （ P 〈 0.01 ）. Conclusion LI model in Wistar rats is more suitable than the one in SD rats.

关 键 词：潜伏抑制 动物模型 SD大鼠 WISTAR大鼠 

分 类 号：R686[医药卫生—骨科学]