丙烯酸树脂RS100和丙烯酸树脂RL100混合包衣制备法莫替丁渗透泵控释片  

Oral osmotic pump tablet of famotidine coated with Eudragit RS100 and Eudragit RL100

作　　者：李红菊[1] 张向荣[1] 刘洪卓[1] 陈存香[1] 李三鸣[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2007年第7期398-401,共4页Journal of Shenyang Pharmaceutical University

摘　　要：目的制备难溶性药物法莫替丁渗透泵型控释片,并考察其释药的影响因素,探讨药物释药规律。方法从渗透促进剂用量、阿拉伯胶用量、衣膜性质、释药孔径和转速等5个因素考察对释药的影响。结果制备了难溶性药物法莫替丁渗透泵型控释片,氯化钠、阿拉伯树脂胶、衣膜厚度是影响释药的主要因素。结论法莫替丁渗透泵型控释片工艺稳定,能够达到12 h明显的恒速释药。Objective To prepare famotidine oral osmotic pump controlled release tablets and investigate the factors influencing the drug release. Methods The optimal formulation and the factors influencing the drug release were selected by the single factor investigation. Results The famotidine oral osmotic pump controlled release tablets were prepared, the effects of the osmotic pressure promoting agent, the amount of acacia and coating thickness were investigated. Conclusions The drug release of famotidine oral osmotic pump con- trolled release tablets is stable during the first 12 h and has obvious characteristic of zero release.

关 键 词：法莫替丁 渗透泵型控释片 恒速释药 

分 类 号：R94[医药卫生—药剂学]