胃痛平糖浆的质量标准  

Quality standard of Weitongping syrup

作　　者：宋欣鑫[1] 张宁[1] 吴昊[2] 谷艳[1] 赵春杰[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]锦州医学院,辽宁锦州121001

出　　处：《沈阳药科大学学报》2007年第7期410-412,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的建立胃痛平糖浆的质量标准。方法采用HPLC法,以Diamonsil C18柱,甲醇-乙腈-水-三乙胺（体积比为70.0∶10.0∶20.0∶0.2）为流动相,在270 nm检测波长处,测定白屈菜红碱的含量,同时对白屈菜进行薄层鉴别。结果白屈菜红碱在0.312-20.000 mg·L^-1内线性关系良好,r=0.999 7。平均加样回收率为101.0%,RSD为1.9%（n=9）,薄层色谱斑点清晰,阴性对照无干扰。结论该方法可有效控制制剂质量 。Objective To establish the quality standard of Weitongping syrup （Chinese meteria medica）. Methods A HPLC method was discribed for the determination of chelerythrine with UV absorbance detection. The separation was performed by using a Diamonsil ODS column with a mobile phase consisting of methanol-acetonitrile-water-triethylamine （ V： V： V = 70.0 ： ： 10.0 ： 20.0 ： 0.2）. The UV detector operated at 270 nm. A TLC method was used for distinguishing Chelidonium majus L. Results The negative comparison displayed no disturbance. The linearity was within the range of 6.25 ng to 400 ng（ r = 0. 999 7）. The average recovery rate was 101.3 % and RSD was 1.9 % （n = 9）. Conclusions The method is suitable for quality control of Weitongping syrup.

关 键 词：胃痛平糖浆 质量标准 白屈菜红碱 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]