腰麻加微量吗啡对剖宫产病人C反应蛋白和白细胞介素2的影响  

Effects of morphine added into spinal anesthetic solution on C-reactive protein and interleukin-2 in patients undergoing Ceasarrian section

作　　者：姜春南[1] 吴卫东[1] 赵宏[2] 施正元[1] 韦宁仙[1] 

机构地区：[1]丹阳市人民医院麻醉科,212300 [2]丹阳市人民医院检验科,212300

出　　处：《江苏医药》2007年第7期675-676,共2页Jiangsu Medical Journal

摘　　要：目的探讨腰麻加微量吗啡对剖宫产病人C反应蛋白(CRP)和白细胞介素2(IL-2)的影响。方法30例择期剖宫产病人,随机分为两组:Ⅰ组(20例),腰麻用药0.75%布比卡因1.8ml+吗啡0.2mg;Ⅱ组(10例),0.75%布比卡因1.8ml。分别于麻醉前(T0)、术后即时(T1)、24h(T2)、72h(T3)采集外周静脉血测定CRP和IL-2水平。结果两组病人麻醉效果满意。与T0相比,两组T2、T3时CRP均明显增高[Ⅰ组:(47.85±16.78)、(43.68±17.54)vs.(4.07±1.7)ng/ml;Ⅱ组:(50.98±32.33)、(44.83±14.88)vs.(3.41±0.80)ng/ml](P<0.01)。T1与T0相比,Ⅰ组IL-2水平明显降低[(4.14±1.96)vs.(4.70±2.11)ng/ml](P<0.01)。结论腰麻加微量吗啡用于术后镇痛不能抑制体内CRP的升高,但对IL-2水平有一过性抑制作用,提示具有一过性免疫抑制作用。Objective To investigate the effects of morphine added into spinal anesthetic solution on C-reactive protein（CRP） and interleukin-2 in patients undergoing Ceasarrian section. Methods Thirty patients undergoing selective Ceasarian section were allocated randomly into two groups. Subrachnoid block was performed with 0. 75 % bupivacaine 1.8 ml alone（group Ⅱ , n： 10） or plus morphine 0. 2 mg（group Ⅰ ,n= 20）. Blood CRP and interleukin-2（IL-2） were detected hefore anesthesia（T0） ,at the end of operation（T1） ,24 h（T2） and 72 h（T3） after operation. Results A good anesthesia was produced in both groups. Compared with TO, CRP at T2 and T3 was significantly increased in both groups（47.85±16.78 and 43.68±17.54 vs. 4.07±1.7 ng/ml for group Ⅰ ,50.98 ±32.33 and 44. 83±14. 88 vs. 3.41±0. 80 ng/ml for group Ⅱ ） （P〈0. 01）. Blood level of IL-2 was significantly lower at T2 than that at TO in group Ⅰ （4.14±1.96 ys. 4. 70±2.11 ng/mD（P〈0. 01）. Conclusion Morphine 0. 2 nag added into spinal anesthetic solution does not inhibit the increase of CRP responsed to surgery but has a transient depressive effect on IL-2 in patients underwent Ceasarian section.

关 键 词：腰麻 吗啡 剖宫产 C-反应蛋白 白细胞介素2 

分 类 号：R614[医药卫生—麻醉学]