Ghrelin与儿童肥胖关系  

Relationship between circulation serum ghrelin level and obesity in children

作　　者：龚海红[1] 陆超[1] 徐华国[2] 

机构地区：[1]南京医科大学第一附属医院儿科,210029 [2]南京医科大学第一附属医院检验科,210029

出　　处：《江苏医药》2007年第7期691-692,共2页Jiangsu Medical Journal

摘　　要：目的探讨新发现的促生长激素释放多肽ghrelin与儿童肥胖的关系。方法采用ELISA方法测定肥胖组8例儿童和正常对照组12例儿童的血清ghrelin水平,同时测定各组儿童的血清胆固醇、甘油三酯,研究其相关性。结果肥胖组儿童ghrelin(39.55±21.42)ng/ml,正常对照组儿童为(10.80±5.98)ng/ml(P<0.01);肥胖组ghrelin水平与甘油三酯呈负相关(P<0.05)。结论肥胖儿童空腹血清ghrelin水平显著升高,ghrelin可能与儿童肥胖的发生有关。Objective To study the correlation of fasting serum ghrelin level with obesity in children. Methods Eight children with simple obesity and twelve healthy children were enrolled in this study. Serum ghrelin levels were determined using ELISA. Blood lipid levels were detected with fully automatic biochemical analyser. Results The levels of serum ghrelin increased significantly in obese children compared to those in healthy children （39.55±21.42 ng/ml vs. 10.80±5.98 ng/ml, P〈0. 01）. The level of serum ghrelin was negatively correlated to triglyceride （r=- 0. 723, P〈 0. 05）. Conclusion The mean serum ghrelin concentration was higher in obese children than that in the healthy children, indicating that ghrelin may be responsible, at least in part, for the hyperphagia observed in obese children.

关 键 词：GHRELIN 肥胖 儿童 

分 类 号：R725[医药卫生—儿科]