缺锌对大鼠海马ACh代谢的影响  

Effect of Zinc Deficiency on The Acetylcholine Content in Rat Hippocampus

作　　者：李积胜[1] 徐鹏霄[1] 

机构地区：[1]天津武警医学院解剖教研室

出　　处：《微量元素与健康研究》1997年第1期11-12,共2页Studies of Trace Elements and Health

基　　金：全军医药科研基金

摘　　要：为了解缺锌在老年性痴呆海马乙酰胆碱（ＡＣｈ）代谢变化中的作用，实验采用放射免疫分析方法，观察缺锌大鼠血浆锌和海马ＡＣｈ水平的变化。结果如下：在缺锌状态下，大鼠血浆锌和海马ＡＣｈ水平均明显降低。提示缺锌可能是触发老年性痴呆海马ＡＣｈ含量降低的重要原因之一。Wistar rats were divided into zinc deficiency group and control group,which were fed with zinc dificient diet and zinc sufficient diet respectively.Two weeks later,the plasma zinc concent and the hippocampal ACh content were measured with atomic absorption and ridioimmunoanalysis methods.The results shown that the plasma zinc contents and the hippocampal ACh contents decreased obversly (P<0 01 or P<0 05).The results suggest that the zinc deficiency is ascociated with the abnormal metabolism of the hippocampal ACh.

关 键 词：锌缺乏 海马 乙酰胆碱 代谢 

分 类 号：R591.1[医药卫生—内科学]