丙酮酸甲酯的合成  

Synthesis of methyl pryvate

作　　者：邱方利[1] 

机构地区：[1]浙江工业大学药学院

出　　处：《化学工程师》2007年第2期48-50,共3页Chemical Engineer

摘　　要：本文介绍了以丙酮酸和无水甲醇为原料,加入合适的催化剂合成丙酮酸甲酯的过程。通过对反应物配比、带水剂、反应时间等影响因素进行对比试验,确定以四氯化碳为带水剂,最佳反应配比为:丙酮酸∶无水甲醇∶四氯化碳=1∶2.5∶0.28,产物收率可达73.9%。该工艺过程简单,易操作,适合工业化大生产。Methyl pyruvate was synthesized by adding to a suitable catalyst with pyruvic acid and absolute methanol. Through changing the factors of influence such as the mix of reactants, different catalyst, and the time of reaction etc. The result showed that the dehydrating agent is carbon tetrachloride, pyruvic acid ： absolute methanol ： carbon tetrachloride = 1： 2.5： 0.28, the yield is 73.9%. The process is simple, operating easily and is fitted to commercial production.

关 键 词：丙酮酸甲酯 丙酮酸 甲醇 合成 

分 类 号：TQ225.24[化学工程—有机化工]