P(NIPAAm-co-AAm)共聚凝胶和PAAc/P(NIPAAm-co-AAm)IPN凝胶的溶胀与释药性能  

Swelling and Drug Releasing Properties of P(NIPAAm-co-AAm) Hydrogels and PAAc/P(NIPAAm-co-AAm) IPN Hydrogels

作　　者：饶燕平[1] 潘春跃[1] 赖金洪[1] 

机构地区：[1]中南大学化学化工学院,长沙410083

出　　处：《应用化学》2006年第10期1129-1134,共6页Chinese Journal of Applied Chemistry

摘　　要：以丙烯酸(AAc)、N-异丙基丙烯酰胺(NIPAAm)和丙烯酰胺(AAm)为原料,N,N-亚甲基双丙烯酰胺(B IS)为交联剂,采用自由基聚合法合成了P(NIPAAm-co-AAm)共聚水凝胶和PAAc/P(NIPAAm-co-AAm)互穿聚合物网络(IPN)水凝胶。研究了两类具有不同温敏特性的凝胶的溶胀与释药性能,并考察了AAm含量对两类凝胶性能的影响。结果表明,P(NIPAAm-co-AAm)共聚水凝胶具有热缩温敏性,当n(AAm)∶n(NIPAAm)由1∶3增加到3∶1时,该共聚水凝胶的有效交联密度由2.518×10-6mol/cm3升高到3.071×10-6mol/cm3,平衡溶胀比由18.65减小至15.36,温敏性减弱,水杨酸释药率由29.87%增大到66.12%,水杨酸钠释药率由95.30%减小到75.55%;与共聚水凝胶相反,PAAc/P(NIPAAm-co-AAm)IPN水凝胶具有热胀温敏性,当n(AAm)∶n(NIPAAm)由1∶3增加到3∶1时,该IPN水凝胶有效交联密度由31.06×10-6mol/cm3下降到26.92×10-6mol/cm3,平衡溶胀比由1.816增大至8.792,温敏性增强,水杨酸释药率由41.56%增大到59.65%,且水杨酸钠释药率由43.77%增大到66.55%。P（NIPAAm-co-AAm） and interpenetrating polymer network （IPN） hydrogels, PAAc/P（NIPAAmco-AAm） with different compositions were prepared from acrylic acid （AAc）, N-isopropylacrylamide （NIPAAm） , and acrylamide（AAm） through free radical polymerization, in which N,N＇-methylenebisacrylamide（BIS） was used as a crosslinking agent. The swelling and drug releasing properties of these hydrogels with different thermosensitive properties were studied. The influence of the amount of AAm on the properties of these hydrogels was investigated. Experimental results revealed that these copolymer gels showed negative temperature sensitivity. When the molar ratio of AAm to NIPAm increased to 3 ： 1 from 1 ： 3, the effective crosslinking density of the copolymer gels increased to 3.071 × 10^-6 mol/cm^3 from 2. 518 × 10^-6 mol/cm^3, and the equilibrium swelling ratio decreased to 15.36 from 18.65; thermosensitivity became weaker, and sodium salicylate releasing ratio of the copolymer gels reduced from 95.30% to 75.55%, and salicylic acid releasing ratio increased from 29. 87% to 66. 12%. However, IPN gels showed positive temperature sensitivity. With increasing the molar ratio of AAm to NIPAm from 1：3 to 3：1, the effective crosslinking density of IPN gels decreased from 31.06 × 10^-6 mol/cm^3 to 26.92 × 10 ^-6 mol/cm^3 and the equilibrium swelling ratio increased to 8.792 from 1. 816; thermosensitivity of the IPN gels increased, and sodium salicylate releasing ratio increased from 41.56% to 59. 65%, and salicylic acid releasing ratio also increased from 43. 77% to 66. 55%.

关 键 词：N-异丙基丙烯酰胺 丙烯酰胺 丙烯酸 共聚 互穿聚合物网络 水凝胶 溶胀 释药 

分 类 号：O631[理学—高分子化学]