手性拆分L-脯氨酸分子印迹聚合物的制备及其性能  

Preparation and Properties of Molecular Imprinting Polymer for Chiral Separation of Proline

作　　者：魏俊[1] 孙向英[1] 刘斌[1] 

机构地区：[1]华侨大学材料科学与工程学院,泉州362021

出　　处：《应用化学》2006年第12期1336-1341,共6页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金(20575023);福建省自然科学基金(D0310016和D0410019)资助项目

摘　　要：以壳聚糖(CTS)为功能基体,以L-脯氨酸(L-Pro)为模板分子,采用分子印迹技术,在水溶液中合成了在空间结构和结合位点上与L-脯氨酸匹配的分子印迹聚合物(L-Pro-M IPs)。利用红外、扫描电镜和热失重分析,对相关化合物进行了表征,并对合成机理进行初步探索;通过对pH值、反应时间、交联剂用量的调节,获得最佳的反应条件为:制备壳聚糖-L-脯氨酸复合物的pH=10.7,干复合物1.0 g,交联剂8 mL,室温下反应18 h。结果表明,在水相中,L-Pro-M IPs对L-Pro具有良好的吸附选择性和高效分离特性,分离因子为4.67。With chitosan as the functional matrix （FMx） and L-Proline （L-Pro） as the template molecule, molecularly imprinting polymer with both the spatial configuration and bonding sites matching to L-Proline was synthesised by means of the molecularly imprinting technology in water. The polymer product was characterized by IR, SEM and TG. Furthermore, the mechanism Was explored preliminarily. The effects of pH, the amount of cross-linking agent and reaction time were studied. The optimum conditions were： pH = 10. 7, composite 1.0 g, cross-linking agent 8 mL, 18 h at ambient temperature. The experimental results show that L-Pro-MIP has a superior selective adsorption capacity and efficient chiral separation of L-Proline in water phase, the resolution factor is 4.67.

关 键 词：手性分离 分子印迹 壳聚糖 脯氨酸 

分 类 号：O658.1[理学—分析化学] O631[理学—化学]