平行催化氢波法测定非甾体抗炎药尼美舒利  

Determination of Nonsteroidal Antiinflammatory Drug Nimesulide via Its Parallel Catalytic Hydrogen Wave

作　　者：马淮凌[1] 凌翠霞[1] 马啸华[1] 

机构地区：[1]商丘师范学院化学系,商丘476000

出　　处：《应用化学》2006年第12期1359-1363,共5页Chinese Journal of Applied Chemistry

基　　金：河南省自然科学基金项目(0511020300);商丘市科技攻关项目(20055001)

摘　　要：在KH2PO4-NaHPO4（pH6．24±0．1）支持电解质中，N-（4-硝基-2-苯氧基苯基）（尼美舒利，nimesulide）甲基磺酰胺产生1个催化氢波，峰电位Ep=-1．20V（vs．SCE）。加入K2S2O8后，该催化氢波被催化，峰电流增加约20倍，峰电位基本不变，产生1个较灵敏的平行催化氢波。其二阶导数峰峰电流以与尼美舒利浓度在4．0×10^-7-8．0×10^-6moL／L范围内呈线性关系（r=0．9886，n=9），检出限为2．0×10^-7mol／L。该方法可用于药物制剂中尼美舒利含量的测定。The catalytic hydrogen wave of nimesulide was measured at ca. - 1.20 V （vs. SCE ） in 0. 10 mol/L KH2PO4-Na2 HPO4 （pH = 6.24 ± 0. 1 ） aqueous solution. When 1.0 × 10^-2 mol/L K2S2O8 is present, the current increases by 20 times, and the peak potential is unchanged, producing a more sensitive parallel catalytic hydrogen wave. The peak current of the parallel catalytic hydrogen wave is proportional to the nimesulide concentration in the range 2.0 × 10^-7 - 80 × 10^-6 mol/L（ r = 0. 988 6, n = 9）. The detection limit is 2.0 × 10^-7 mol/L. The proposed method can be applied to the determination of nimesulide in pharmaceuticals without preliminary separation.

关 键 词：尼美舒利 过二硫酸钾 催化氢波 平行催化氢波 

分 类 号：O657[理学—分析化学]