无锡地区健康人群血清TNF-α、IFN-γ浓度的分布  

Investigation on Serum TNF-α and IFN-γ Reference Value of Health Donors in Wuxi

作　　者：胡瑜[1] 周桓[1] 王丰[1] 陈敏[1] 樊黎[1] 

机构地区：[1]江苏省无锡市第四人民医院检验科,214062

出　　处：《临床输血与检验》2007年第3期237-239,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的研究无锡地区健康人群血清肿瘤坏死因子-α(tumornecrosis factor-α,TNF-α)、干扰素-γ(interferon-γ,IFN-γ)水平的参考值范围。方法采用酶联免疫吸附实验测定健康志愿者以及肿瘤患者血清TNF-α、IFN-γ浓度,分析不同性别、年龄组人群血清浓度的差异,以及正常人与肿瘤患者血清TNF-α、IFN-γ浓度的差异。结果正常人血清TNF-α、IFN-γ浓度分别为(9.42±2.91)ng/ml和(10.57±3.58)ng/ml,性别间差异无显著性(P>0.05),20～70岁年龄人群血清TNF-α或IFN-γ浓度的差异无显著性(P>0.05);肿瘤患者血清TNF-α、IFN-γ浓度分别为(22.50±9.06)ng/ml和(18.08±8.95)ng/ml,显著高于正常人(P<0.05)。结论无锡地区健康人血清TNF-α、IFN-γ参考值范围分别为(3.72～15.11)ng/mg、(3.58～17.58)ng/mg;肿瘤患者血清TNF-α、IFN-γ水平显著高于健康人。Objective To study tumor necrosis factor-α （TNF-α）,interferon-γ （IFN-γ） reference values of healthy donors in Wuxi region. Methods Serum concentrations of TNF-α and IFN-γ in healthy donors or patients with malignancy were measured with enzyme-linked immunosorbent assay （ELISA）. Statistical methods were employed to analyze distribution characteristics of TNF-α and IFN-γ in healthy donors. The disributions of gender and age were analyzed and the differences of TNF-α and interferon-γ between health donors and cancer patients were also investigated. Results The serum concentration of TNF-α and IFN-γ in healthy donors were （9. 42±2. 91） ng/ml and （10. 57±3. 58） ng/ml respectively. There was no significant difference between genders or ages from 20 to 70. In patients with malignancy,serum concentrations of TNF-α or IFN-γ were （22.50±9.06） ng/ml or （18.08±8.95） ng/ml respectively, and were significantly higher than those in healthy donors. Conclusion In Wuxi, the serum concentrations of TNF-α or IFN-γ in healthy donors were （3.72～15.11） ng/mg and （3. 58～17.58） ng/mg respectively. The serum concentration of TNF-α and IFN-γ in patients with melanoma were significantly higher than those in healthy donors.

关 键 词：肿瘤坏死因子 干扰素 

分 类 号：R446.62[医药卫生—诊断学]