不明原因复发性流产的主动免疫治疗  

Immunotherapy of Unexplained Recurrent Spontaneous Abortion

作　　者：吴菁[1] 黄艳仪[1] 黄华梅[1] 尹爱华[1] 钟燕芳[1] 潘小英[1] 

机构地区：[1]广东省妇幼保健院,广东广州510010

出　　处：《赣南医学院学报》2007年第3期392-393,共2页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨主动免疫治疗对不明原因复发性流产的疗效,及不同免疫治疗次数疗效的比较。方法:将56例诊断为不明原因复发性流产,封闭抗体检测阴性的患者分为A、B两组,进行2次或3次的免疫治疗,每次间隔4周。观察封闭抗体在治疗前后的比较及受孕后妊娠结局。结果:A组22例患者治疗后17例受孕,14例足月分娩,妊娠成功率为82.35%。B组34例患者治疗后28例受孕,24例足月分娩,成功率为85.71%。两组无显著性差异。结论:主动免疫治疗对原因不明的复发性流产具有良好的治疗效果,为避免免疫治疗的潜在风险,免疫治疗次数可选择2次。Objectives： To investigate the efficiacy of immunothrapy in women with unexplained recurrent spontaneous abortion （URSA） and different times of immunization. Method ： 34 URSA patients were randoraly divided into A and B two groups. The immunization was achieved by injection of the paternal leukocyte for twice or 3 times at an internal of 4 weeks. Blocking antibodies and the outcome of pregnancy were analysed. Result： The successful pregnancy rate was 82.35% （14/17） in A group and was 85.71% （24/ 28） in B group. There was also no signisficant difference between the two groups. Conclusion： Immunotherapy with lymphocytes is ef- feefive in treating URSA. To avoid the side effects of immunotherapy, active immunization could be reduce from 3 to 2 times.

关 键 词：复发性流产 主动免疫治疗 封闭抗体 

分 类 号：R714.21[医药卫生—妇产科学]