咳喘宁对病毒诱发哮喘患儿Th亚群的调节作用  

Effect of Kechuanning on Adjusting Cytokine in Children with Virus-induced Asthma

作　　者：王孟清[1] 罗银河[1] 陈锡军[1] 朱晔[1] 刘克丽[1] 莫非钧[1] 舒兰[1] 

机构地区：[1]湖南中医药大学第一附属医院,长沙410007

出　　处：《中华中医药杂志》2007年第7期481-483,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省社会发展基金资助课题(No.04SK3056)

摘　　要：目的:观察咳喘宁对病毒诱发哮喘患儿Th亚群细胞因子表达的影响。方法:120例病毒诱发哮喘患儿随机分为咳喘宁治疗组60例和西药对照组60例,分别采用咳喘宁、利巴韦林治疗,观察两组患儿治疗后血清中IL-12I、L-4的含量变化。结果:咳喘宁能显著提高患儿血中IL-12,降低IL-4,其作用明显优于对照组。结论:咳喘宁治疗病毒诱发小儿哮喘的机制可能与提高患儿IL-12水平、降低IL-4水平有关。Objective： To observe the effect of Kechuanning on Th cytokine expression in pediatric virus-induced asthma. Methods： 120 cases of pediatric virus - induced asthma were randomly divided into Kechuanning group （treatment group, n = 60, treated with Kechuanning） and Western medicine group （control group, n = 60, treated with virazole）. The change of Thl cytokine IL-12 and Th2 cytokine IL-4 in blood serum were detected and analyzed. Results： Kechuanning could increase IL-12 but decrease IL-4 level in the patient＇s blood, therefore regulate Th cell subset, and the effect was more obvious than in control group. Conclusion： The mechanism of Kechuanning in curing pediatrics asthma induced by virus was related with increasing IL-12 and decreasing IL-4 level.

关 键 词：哮喘 咳喘宁 白细胞介素4 白细胞介素-12 

分 类 号：R272[医药卫生—中医儿科学]