持续电针刺激调节创伤大鼠脾淋巴细胞体外增殖反应的动态观察  

DYNAMIC OBSERVATION ON RAGULATION ON SPLEEN LYMPHOCYTE PROLIFERATION FROM THE TRAUMATIZED RATS IN VITRO OF CONTINUED ELECTROACUPUNCTURE

作　　者：程晓东[1] 吴根诚[1] 姜建伟[1] 杜莅娜[1] 曹小定[1] 何球藻[2] 

机构地区：[1]上海医科大学医学神经生物学国家重点实验室 [2]上海医科大学基础医学院免疫学教研室

出　　处：《中国免疫学杂志》1997年第2期68-70,共3页Chinese Journal of Immunology

基　　金：国家攀登计划项目基金

摘　　要：动态观察了持续电针刺激对创伤大鼠脾淋巴细胞体外增殖反应的调节作用。结果显示：创伤后第１、３、５、７天大鼠脾淋巴细胞在体外对ＣｏｎＡ的增殖反应明显降低，第３天达最低水平，第１０天恢复正常；创伤后不同天数的大鼠血清对正常小鼠脾淋巴细胞体外增殖反应具有相应的抑制作用；持续电针刺激“足三里”等穴位不仅能防止创伤大鼠脾淋巴细胞增殖率的下降，而且可有效地消除血清的抑制作用。提示：持续电针刺激可以改善创伤大鼠的免疫功能。The regulation on spleen lymphocyte proliferation from the injured rats of continued electroacupuncture(EA) was observed dynamically.The results showed that the proliferation response to ConA of the rat spleen lymphocytes was significantly decreased on day 1,3,5,7 and the minimum level was on day 3 after the operative trauma.The proliferation was reversed to nearly normal on day 10.The corresponding inhibitory effect of the rat serum on proliferation of normal mouse spleen lymphocytes at the same periods after trauma was observed.Continued EA stimulation on day1,3,5,7 prevent not only the decrease of proliferation of the injured rat splenocytes,but also the inhibition of the rat serum.This indicated that the immune function may be improved by continued EA after trauma stress.

关 键 词：创伤 应激 淋巴细胞转化 免疫抑制因子 电针刺激 

分 类 号：R392.12[医药卫生—免疫学] R245.97[医药卫生—基础医学]