补肾中药对SRBC免疫后老年大鼠脑组织中M和β受体功能的影响  

THE EFFECT OF KIDNEY BENEFITING CHINESE HERBAL MEDICINE ON THE FUNCTION OF M AND β RECEPTORS IN BRAIN AFTER IMMUNIZED AGED RATS USING SRBC

作　　者：莫启忠[1] 宫斌[1] 方军[1] 马骏[1] 陈坤华[1] 匡兴伟[1] 王菊美[1] 王宝妹[1] 黄琦[1] 

机构地区：[1]上海中医药大学核医学研究室

出　　处：《中国免疫学杂志》1997年第2期90-93,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金

摘　　要：用ＲＲＬＢＡ测定ＡＲ和ＳＲＢＣ免疫后ＡＲ脑不同分区组织中Ｍ和β受体的Ｒｔ值，观察补肾中药对它们脑组织中Ｍ和β受体Ｒｔ值的影响，以西药喜德镇和中药首乌片为对照药，探讨补肾中药延缓脑组织衰老的机理。实验证实：ＳＲＢＣ免疫后ＡＲ脑组织中Ｍ和β受体Ｒｔ值显著降低，补肾中药能显著拮抗ＳＲＢＣ对Ｎ负反馈作用所引起的脑组织中Ｍ和β受体Ｒｔ值降低，其作用与治疗老年性痴呆的西药喜德镇相似。结果为补肾中药防治老年性痴呆病提供了实验依据。It were determined to M and β receptors of differencs brain area for the aged rats after immunized aged rats using SRBC with receptors radioligand binding assay(RRLBA).Observed the effect of Kidney Benefiting chinese Herbal Medicine(KBCHM) on the function of M and β receptors in brain of the aged rats and after immunized aged rats using SRBC.Used Hydergine as Western Medicine Contrast Group, ShouWuPian as chinese medicine contrast group, to inquire into mechanism of KBCHM delaying degeration of brain. The experiments were shown that M and β receptors were decreased obviously in brain after immunized aged rats using SRBC. KBCHM that was similar with Hydergine curing senile dementia can against obviously reducing the founction of M and β receptors in brain cause of SRBC negative feedback to neurotransmitters(NT). This suggested that KBCHM can prevent and cure senile dementia.

关 键 词：补肾中药 SRBC免疫 脑组织 中药 M受体 Β受体 

分 类 号：R285.5[医药卫生—中药学]