妊高征患者血浆及血小板中5-羟色胺含量的测定  

The Change of Serotonin of Venous Blood in Pregnancy Induced Hypertension

作　　者：任东平[1,2] 杨梦庚[1,2] 罗亚宁 李东红 王丽丽[1,2] 

机构地区：[1]北京空军总医院妇产科 [2]第四军医大学唐都医院妇产科 中心实验室

出　　处：《中华妇产科杂志》1997年第1期12-14,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨５－羟色胺（５－ＨＴ）与妊高征发病的关系。方法：采用荧光分光光度法测定３１例妊高征患者（妊高征组）、２０例正常孕晚期妇女（正常晚孕组）静脉血血小板及血浆５－ＨＴ含量。结果：妊高征组静脉血血小板５－ＨＴ含量（２４．６９±１７．７９μｇ／Ｌ）明显低于正常晚孕组（９１．０６±４７．７７μｇ／Ｌ）（Ｐ＜０．０１），血浆５－ＨＴ含量（４８．６５±１９．２９μｇ／Ｌ）明显高于正常晚孕组（３５．３９±１２．８８μｇ／Ｌ）（Ｐ＜０．０１）。结论：血小板释放５－ＨＴ异常增多，可能是造成妊高征患者血浆５－ＨＴ含量增高的原因；血浆５－ＨＴ含量增高与妊高征一系列病理改变有密切关系。Objective: To provide evidence to the hypothesis that the involvement of serotonin (5 HT) takes part in the pathogenesis of pregnancy induced hypertension (PIH). Method: 31 pregnant women with PIH and 20 normotensive pregnant women were studied in the present study. Venous plasma 5 HT and platelet 5 HT from all subjects were measured with spectrometry. Results: The mean platelet 5 HT level in PIH group (24.69±17.79 μg/L) was less than that in normotensive group (91.06 ±47.77μg/L) ( P <0.01). The mean plasma 5 HT level in PIH group (48.65±19.29μg/L) was significantly higher than that in normotensive group (35.39±12.88μg/L) ( P <0.01). Conclusion: Plasma levels of 5 HT in PIH were elevated significantly, this might be largely caused by the increased release of 5 HT by platelet. The results show that elevated level of 5 HT in patients with PIH might take part in the pathogenesis of PIH.

关 键 词：妊娠高血压 综合征 血浆 血小板 血清素 

分 类 号：R714.246[医药卫生—妇产科学]