电刺激诱发大鼠中央杏仁核多巴胺释放量与性别关系  

THE RELATIONSHIP BETWEEN SEX AND DOPAMINE RELEASE FROM CENTRAL AMYGDALOID NUCLEUS EVOKED BY ELECTRIC STIMULATION IN RATS

作　　者：谢俊霞[1] 唐明[1] OertelWH EarlCD 

机构地区：[1]青岛医学院生理学教研室

出　　处：《青岛医学院学报》1997年第1期5-8,共4页Acta Academiae Medicinae Qingdao Universitatis

基　　金：德国联邦政府研究与技术基金

摘　　要：①目的探讨电刺激诱发的大鼠中央杏仁核（ＣｅＡ）多巴胺（ＤＡ）释放量与性别的关系。②方法用快速周期伏安测定法，测定了电刺激腹侧背盖区（ＶＴＡ）引起的不同性别动物ＣｅＡ的ＤＡ释放量。③结果雌鼠和雄鼠ＣｅＡ的ＤＡ释放量均具有刺激强度、刺激脉冲和刺激频率依赖关系；在相同刺激条件下，雌性大鼠ＤＡ释放量明显高于雄性。④结论大鼠ＣｅＡ的ＤＡ释放量与电刺激参数有量效关系，而且部分受雌激素的控制。Objective To investigate the relationship between sex and dopamine(DA) release from central amygdaloid nucleus evoked by electric stimulation in rats. Methods In vivo fast cyclic voltammetry was used to measure DA release from male and female rats CeA. Results DA release in male and female rats was dependent upon the stimulation intensity, number of pulses and frequencies. With the same stimulation parameters, DA release from female rats was significantly higher than from male rats. Conclusion There is an input/output relation between DA release and electric stimulation parameters. And DA release was partly regulated by estrogen.

关 键 词：中央杏仁核 多巴胺 性别 电刺激 

分 类 号：R338.26[医药卫生—人体生理学]