清醒无拘束豚鼠气道反应性特点  

CHARACTERISTICS OF AIRWAY REACTIVITY IN CONSCIOUS AND UNRESTRAINED GUINEA PIGS

作　　者：张纬萍[1] 陆智勇[1] 吴仁毅[1] 居星耀 魏尔清[2] 

机构地区：[1]浙江医科大学基础医学院神经生物学实验室 [2]浙江医科大学基础医学院药理学教研室

出　　处：《浙江医科大学学报》1997年第1期1-5,共5页

基　　金：国家自然科学基金!39270789

摘　　要：作者通过对清醒无拘束豚鼠对组胺、乙酰胆碱和抗原气道反应性的研究，发现有以下特点：呼吸变化在24h连续可测；吸入组胺（His）和乙酰胆碱（ACh）后的引喘作用有浓度依赖性，半数有效引喘浓度（EC50）分别为53．3μmol／m3和269μmol／m3；对His的反应有昼夜节律性；致敏豚鼠吸入抗原可以诱发哮喘反应，在30min内最明显，吸抗原后6h对ACh的反应性增强。In the conscious and unrestrained guinea pigs, we found the following characteristics: (1)The response to histamine(His) or acetylcholine (ACh) aerosol was concentration-dependent on EC50(the effective concentration that causes 50% animals to wheeze)of 53. 3μmol/m3,and 269μmol/m3 respectively. (2)Antigen (OA) induced a lasting wheezing for about 30 min,and the response to ACh increased after inhalation of antigen in the sensitized guinea pigs. (3) The response to His aerosol showed a circadian variation.

关 键 词：气道阻力 哮喘 病因学 

分 类 号：R562.250.2[医药卫生—呼吸系统]