酚妥拉明对肝硬变门静脉高压症患者门静脉压力的影响  

Effect of phentolamine on portal pressure in cirrhotic patients with portal hypertension

作　　者：朱继业[1] 冷希圣[1] 殷军[1] 李澍[1] 陈雷[1] 杜如昱[1] 

机构地区：[1]北京医科大学人民医院普通外科

出　　处：《中华外科杂志》1997年第2期92-94,共3页Chinese Journal of Surgery

基　　金：国家自然科学基金;卫生部青年基金

摘　　要：作者观察了１４例经病理确诊为坏死后肝硬变门静脉高压症患者及７例无肝脏疾病及肝脏转移的大肠癌患者周围静脉输入α肾上腺受体拮抗剂酚妥拉明前后肝静脉楔入压（ＷＨＶＰ）和门静脉压（ＰＶＰ）的变化情况。结果显示酚妥拉明能够有效地降低肝硬变门静脉高压症患者的ＷＨＶＰ和ＰＶＰ，（０．５６～０．６３ｋＰａ，０．４２～０．５０ｋＰａ，Ｐ＜０．０１），但同时对动脉舒张压和心率有一定影响（动脉舒张压下降０．９４～１．２７ｋＰａ，心率上升８．６７～１０．６７次／分），酚妥拉明对没有肝脏疾病和门静脉高压症的患者没有降低门静脉压力的作用。Changes of hepatic venous wedge pressure(WHVP) and portal venous pressure(PVP) in fourteen patients with postnecrotic cirrhosis proved pathologically and seven patients with colon carcinoma without hepatopathy were observed before and after the infusion of α adrenergic receptor antagonist phentolamine from peripheral venous.The results indicate that phentolamine can reduce WHVP and PVP of cirrhotic patients with portal hypertension efficiently(0 56￣0 63kPa,0 42￣0 50kPa,respectively, P <0 01),but it effects arterial diastolic pressure and heart rate simultaneously ( arterial diastolic pressure reduced by 0 94￣10 7kPa,while heart rate increased by 8 67￣10 67per minute).Phentolamine doec not reduce portal pressure on patients without portal hypertension.

关 键 词：肝硬变 门脉高血压 酚妥拉明 药物疗法 

分 类 号：R657.340.5[医药卫生—外科学] R657.31[医药卫生—临床医学]