烧伤早期大鼠血浆、皮肤创面及脏器内皮素-1的动态变化  

STUDY ON THE DYNAMIC CHANGES OF LEVEL OF ENDOTHELIN IN THE PLASMA AND ORGANS AND BURNED SKIN IN RATS AFTER THERMAL INJURY

作　　者：贾晓明[1] 朱兆明[1] 曾强 范英鲜 孔秋华[1] 秦勤 余满松 

机构地区：[1]解放军第304医院 [2]解放军总医院 [3]人民军医出版社

出　　处：《解放军医学杂志》1997年第1期40-42,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然基金

摘　　要：采用雄性Ｗｉｓｔａｒ大鼠３５％Ⅲ度烧伤模型，于伤前、伤后共８个时点，分别检测血浆、皮肤创面及心、肺、肝、肾、肠５种脏器的内皮素－１（ＥＴ－１）含量。实验发现，血浆ＥＴ－１含量伤后１ｈ升高，８ｈ达到峰值，并持续升高直至伤后２４ｈ（Ｐ＜０．０５）。皮肤ＥＴ－１伤前值高于５种脏器的２．３～１１倍，伤后１ｈ显著升高（Ｐ＜０．０１），８ｈ达到峰值。５种脏器ＥＴ－１水平在伤后８ｈ达到峰值（Ｐ＜０．０１），其中以肠、肺升高为著。推断烧伤早期血浆中ＥＴ－１异常升高，可能主要来自于皮肤创面，其次来自于上述５种脏器。The level of ET 1 in the plasma and five organs (heart,lung,liver,kidney and intestine) and burned skin were measured by specific radio immunoassay ( 125 Ⅰ)in Wistar rats with 35% TBSA Ⅲ° burn.The rats were divided in eight different time groups.It was found that severe burn often led to a rise of ET 1 in the plasma and five organs 72 hours postburn.The contents of ET 1 in skin were higher than that in plasma and five organs.The results indicated that the high contents of ET 1 in plasma may be contributed by burned skin and five organs.

关 键 词：烧伤 创面 血浆 器官 内皮素 内皮细胞 

分 类 号：R644[医药卫生—外科学]