白细胞介素-4和γ-干扰素在哮喘发病机制中的研究  

THE ROLE OF INTERLEUKIN 4 AND INTERFERON γ IN THE PATHOGENESIS OF ASTHMA

作　　者：王华强[1] 张世明[1] 李强[1] 

机构地区：[1]济南军区总医院 [2]第二军医大学长海医院

出　　处：《解放军医学杂志》1997年第1期57-59,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：对发作期哮喘和慢性阻塞性肺疾病（ＣＯＰＤ）病人及正常人各２０例，检测外周血淋巴细胞（ＰＢＬＣｓ）培养上清液中白细胞介素－４（ＩＬ－４）含量、γ－干扰素（ＩＦＮ－γ）活性及其血清ＩｇＥ总浓度。结果表明，发作期哮喘组ＩＬ－４和ＩｇＥ均明显高于ＣＯＰＤ组及正常对照组（Ｐ＜０．００１）。ＩＬ－４和ＩＦＮ－γ及ＩＦＮ－γ与ＩｇＥ均呈负相关（ｒ＝－０．４８，－０．７５；Ｐ＜０．０５，０．００１）。而ＣＯＰＤ组与正常对照组之间的ＩＬ－４和ＩｇＥ无显著差异（Ｐ＞０．０５）。３组之间ＩＦＮ－γ活性亦无差异（Ｐ＞０．０５）。提示ＩＬ－４和ＩＦＮ－γ之间的相互平衡是哮喘发病过程中血清ＩｇＥ浓度调节的一种重要因素。In order to study the role of interleukin 4(IL 4) and interferon γ(IFN γ) in the pathogenesis of asthma,IL 4 level and IFN γ activity in the supernatants of perpherial blood lymphayte cells(PBLCs) and total serum IgE concentration were measured by ELISA and MCDI method respectively in 20 patients with asthma and 20 patients with chronic obstructive pulmonary disease (COPD) and in normal controls.The rusults showed that IL 4 and IgE levels in the attack of asthma were markedly elevated compaired with those of COPD and normal controls( P <0 001).There exists a positive correlation between IL 4 and IgE( r =0 82, P <0 001),a negative correlation between IL 4 and IFN γ ( r =-0 48, P <0 05).Additionally,IFN γ activity was negatively correlated to IgE level( r =0 75, P <0 01).IL 4 and IgE levels in patients with COPD were not signifincantly different from those of normal controls ( P >0 05).There was no significant difference in IFN γ activity among the three groups( P >0 05).The results indicated that the imbalance between IL 4 and IFN γ plays a key role in the regulation of serum IgE concentration during asthma attack.

关 键 词：哮喘 白细胞介素-4 Γ-干扰素 免疫球蛋白E类 

分 类 号：R562.250.2[医药卫生—呼吸系统]