黄甘草异黄酮成分的研究  

ISOFLAVONES FROM GLYCYRRHIZA EURYCARPA

作　　者：张聿梅[1] 许旭东[1] 胡碧煌[1] 刘勤[1] 侯翠英[1] 杨峻山[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所

出　　处：《药学学报》1997年第4期301-304,共4页Acta Pharmaceutica Sinica

摘　　要：从黄甘草（ＧｌｙｃｙｒｒｈｉｚａｅｕｒｙｃａｒｐａＰ．Ｃ．Ｌｉ）根及根茎中分得五个异黄酮化合物，根据理化性质及光谱（ＵＶ，ＭＳ，１ＨＮＭＲ，１３ＣＮＭＲ，ＮＯＥ，ＨＭＢＣ）数据分析，化合物Ｉ的结构推定为７，２′，４′三羟基３′异戊烯基异黄酮，为一新化合物，命名为黄甘草异黄酮Ａ（ｅｕｒｙｃａｒｐｉｎＡ）。化合物Ｉ的结构推定为７，２′二羟基（２″，３″∶４′，３′）６″，６″二甲基吡喃异黄酮，为一新的天然产物，命名为黄甘草异黄酮Ｂ（ｅｕｒｙｃａｒｐｉｎＢ）。其余化合物分别鉴定为ｌｉｃｏｉｓｏｆｌａｖｏｎｅＡ（ＩＩＩ），毛蕊异黄酮（ｃａｌｙｃｏｓｉｎ，ＩＶ）和芒柄花素（ｆｏｒｍｏｎｏｎｅｔｉｎ，Ｖ）。化合物ＩＩ～Ｖ均为首次从本植物中得到。A new isoflavone, named eurycarpin A and a new natural product isoflavone named eurycarpin B have been isolated from the roots of Glycyrrhiza eurycarpa P.C.Li. Their structures were determined to be 7,2′,4′ trihydroxy 3′ (3,3 dimethylallyl) isoflavone(I) and 7,2′ dihydroxy 6″,6″ dimethylpyrano (2″,3″∶4′,3′)isoflavone(II) on the basis of spectroscopic analysis (UV,EI MS, 1HNMR, 13 CNMR, NOE difference and HMBC). In addition, three known isoflavones, licoisoflavone A, calycosin and formononetin, were obtained for the first time from this plant.

关 键 词：黄甘草 异黄酮 异黄酮A 异黄酮B 中药化学成分 

分 类 号：R284.1[医药卫生—中药学]