加兰它敏(Galanthamine)的合成方法  

Research Progress on Synthesis Methods of Alanthamine

作　　者：杨青[1] 郑由浒[1] 唐瑞仁[1] 

机构地区：[1]中南大学化学化工学院,湖南长沙410083

出　　处：《精细化工中间体》2007年第2期13-16,24,共5页Fine Chemical Intermediates

摘　　要：生物碱加兰它敏为可逆性乙酰胆碱酯酶(AChE)的抑制剂,对阿尔海默氏老年痴呆症有较好的疗效,介绍了以K3[Fe(CN)6]、钯络化物、三价碘化物等为氧化剂的氧化关环方法合成加兰它敏的方法,并总结了各种其外消旋体的拆分方法,简要评价了各种方法的优缺点。The natural alkaloid galanthamine which acts as a inhibitor of acetylcholine esterase, is a new drug for curing Alzheimer＇s disease. The synthesis methods of galanthamine via phenolic coupling step using K3 [Fe（CN）6], palladium-complex and iodine （ Ⅲ ） reagent as oxidant were introduced, and racemic resolution methods for galanthamine were summarized. Findlly, their advantage and disadvantage of synthetic and resolutions methods of galanthamine were put forwarded.

关 键 词：加兰它敏 阿尔海默氏 乙酰胆碱酯酶抑制剂 

分 类 号：TQ464[化学工程—制药化工]