A facile stereospecific synthesis of (Z)-2-sulfonyl-substituted 1,3-enynes via Sonogashira coupling of (E)-α-iodovinyl sulfones with 1-alkynes  

作　　者：Wen Yan Hao Jian Wen Jiang Ming Zhong Cai 

机构地区：[1]Department of Chemistry, Jiangxi Normal University, Nanchang 330022, China

出　　处：《Chinese Chemical Letters》2007年第7期773-776,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.20462002);Natural Science Foundation of Jiangxi Province(No.0420015)for financial support.

摘　　要：（E）-α-Iodovinyl sulfones 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd（PPh3）4 and 10 mol% of CuI to stereospecifically afford the corresponding （Z）-2-sulfonyl-substituted 1,3-enynes 3 in high yields.（E）-α-Iodovinyl sulfones 1 underwent the Sonogashira coupling reactions with terminal alkynes 2 in piperidine at room temperature in the presence of 5 mol% of Pd（PPh3）4 and 10 mol% of CuI to stereospecifically afford the corresponding （Z）-2-sulfonyl-substituted 1,3-enynes 3 in high yields.

关 键 词：（E）-α-Iodovinyl sulfone 1 3-Enynylsulfone Sonogashira coupling Terminal alkyne 

分 类 号：O623.124[理学—有机化学] O623.8[理学—化学]