Thermodynamic study on the interaction between anti-tumor drug tegafur and human serum albumin  

作　　者：Lin Wei Li Dong Dong Wang De Zhi Sun Min Liu You Ying Di Hua Chao Yan 

机构地区：[1]College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China

出　　处：《Chinese Chemical Letters》2007年第7期891-894,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China （No. 20543004）; the Natural Science Foundation of Shandong Province （No. 2004zx15） ; the Science Foundation of Liaocheng University （No.31801）.

摘　　要：The changes of thermodynamic properties of the system on interaction between tegafur and human serum albumin （HSA） and the changes of secondary structure units of HSA in the system at 298.15 K have been investigated by the Nano-Watt-Scale isothermal titration calorimetry （ITC）, the Langmuirs binding model and the circular dichroism （CD） spectrometry.The changes of thermodynamic properties of the system on interaction between tegafur and human serum albumin （HSA） and the changes of secondary structure units of HSA in the system at 298.15 K have been investigated by the Nano-Watt-Scale isothermal titration calorimetry （ITC）, the Langmuirs binding model and the circular dichroism （CD） spectrometry.

关 键 词：TEGAFUR Human serum albumin Isothermal titration calorimetry Circular dichroism 

分 类 号：R979.1[医药卫生—药品] R917[医药卫生—药学]